Cell atlas - ATP6V0A1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ATP6V0A1
Gene description	ATPase, H+ transporting, lysosomal V0 subunit a1
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus & vesicles. In addition localized to the cytosol & nuclear speckles.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved), Vesicles (supported)
Additional location	In addition localized to the Nuclear speckles (uncertain), Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA022144
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus & vesicles. In addition localized to the cytosol & nuclear speckles.

Main location

Golgi apparatus (approved), Vesicles (supported)

Additional location

Nuclear speckles (uncertain), Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA022144	A-431	Golgi apparatus
HPA022144	A-431	Vesicles
HPA022144	U-251 MG	Nuclear speckles
		Golgi apparatus
		Cytosol

GENE INFORMATION
Gene name	ATP6V0A1 (HGNC Symbol)
Synonyms	a1, ATP6N1, ATP6N1A, Stv1, Vph1, VPP1
Description	ATPase, H+ transporting, lysosomal V0 subunit a1 (HGNC Symbol)
Entrez gene summary	This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	42458844 - 42522611
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000033627 (version 83.38)
Entrez gene	535
UniProt	Q93050 (UniProt - Evidence at protein level)
neXtProt	NX_Q93050
Antibodypedia	ATP6V0A1 antibodies

PROTEIN BROWSER

ATP6V0A1-001	ATP6V0A1-003	ATP6V0A1-004	ATP6V0A1-005	ATP6V0A1-006	ATP6V0A1-012	ATP6V0A1-013	ATP6V0A1-014	ATP6V0A1-017	ATP6V0A1-022	ATP6V0A1-025	ATP6V0A1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP6V0A1-001 ENSP00000377415 ENST00000393829	Q93050 [Direct mapping] V-type proton ATPase 116 kDa subunit a isoform 1 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006879 [cellular iron ion homeostasis] GO:0007035 [vacuolar acidification] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0030670 [phagocytic vesicle membrane] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0042470 [melanosome] GO:0043231 [intracellular membrane-bounded organelle] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0051117 [ATPase binding] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] GO:0090382 [phagosome maturation] Show all	831 aa 95.8 kDa	No	7
ATP6V0A1-003 ENSP00000443991 ENST00000537728	B7Z641 [Direct mapping] V-type proton ATPase subunit a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain] GO:0007035 [vacuolar acidification] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] Show all	788 aa 90.5 kDa	No	7
ATP6V0A1-004 ENSP00000264649 ENST00000264649	Q93050 [Direct mapping] V-type proton ATPase 116 kDa subunit a isoform 1 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006879 [cellular iron ion homeostasis] GO:0007035 [vacuolar acidification] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0030670 [phagocytic vesicle membrane] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0042470 [melanosome] GO:0043231 [intracellular membrane-bounded organelle] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0051117 [ATPase binding] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] GO:0090382 [phagosome maturation] GO:1901998 [toxin transport] Show all	838 aa 96.6 kDa	No	7
ATP6V0A1-005 ENSP00000466878 ENST00000585525	B7Z2A9 [Direct mapping] V-type proton ATPase subunit a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain] GO:0007035 [vacuolar acidification] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] Show all	794 aa 91.2 kDa	No	7
ATP6V0A1-006 ENSP00000342951 ENST00000343619	Q93050 [Direct mapping] V-type proton ATPase 116 kDa subunit a isoform 1 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000220 [vacuolar proton-transporting V-type ATPase, V0 domain] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006879 [cellular iron ion homeostasis] GO:0007035 [vacuolar acidification] GO:0008286 [insulin receptor signaling pathway] GO:0010008 [endosome membrane] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0030670 [phagocytic vesicle membrane] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0033572 [transferrin transport] GO:0034220 [ion transmembrane transport] GO:0042470 [melanosome] GO:0043231 [intracellular membrane-bounded organelle] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0051117 [ATPase binding] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] GO:0090382 [phagosome maturation] Show all	837 aa 96.4 kDa	No	7
ATP6V0A1-012 ENSP00000466328 ENST00000587824	K7EM24 [Direct mapping] V-type proton ATPase subunit a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007035 [vacuolar acidification] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0043231 [intracellular membrane-bounded organelle] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] Show all	130 aa 15.4 kDa	No	0
ATP6V0A1-013 ENSP00000466290 ENST00000589213	K7ELZ6 [Direct mapping] V-type proton ATPase subunit a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007035 [vacuolar acidification] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] Show all	93 aa 10.9 kDa	No	0
ATP6V0A1-014 ENSP00000467373 ENST00000589727	K7EPG4 [Direct mapping] V-type proton ATPase subunit a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007035 [vacuolar acidification] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] Show all	198 aa 23 kDa	No	0
ATP6V0A1-017 ENSP00000466767 ENST00000592324	K7EN36 [Direct mapping] V-type proton ATPase subunit a Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007035 [vacuolar acidification] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] Show all	195 aa 22.5 kDa	No	0
ATP6V0A1-022 ENSP00000466852 ENST00000588138	K7ENA1 [Direct mapping] V-type proton ATPase subunit a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0007035 [vacuolar acidification] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] Show all	191 aa 21.2 kDa	No	2
ATP6V0A1-025 ENSP00000468177 ENST00000586201	K7ERA6 [Direct mapping] V-type proton ATPase subunit a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0007035 [vacuolar acidification] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] Show all	188 aa 20.8 kDa	No	1
ATP6V0A1-201 ENSP00000446377 ENST00000544137	F5H1T6 [Direct mapping] V-type proton ATPase subunit a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0007035 [vacuolar acidification] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015986 [ATP synthesis coupled proton transport] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0016471 [vacuolar proton-transporting V-type ATPase complex] GO:0033179 [proton-transporting V-type ATPase, V0 domain] GO:0046961 [proton-transporting ATPase activity, rotational mechanism] GO:0070072 [vacuolar proton-transporting V-type ATPase complex assembly] Show all	483 aa 55.2 kDa	No	7