Expression of ASTE1 in cancer - Summary

GENERAL INFORMATION
Gene name	ASTE1
Gene description	Asteroid homolog 1 (Drosophila)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in basal layer of male genitalia, transitional, respiratory and squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA037010 , HPA037011
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), endometrial cancer (unfavourable) and cervical cancer (favourable).
Liver cancer p<0.001 Endometrial cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA037010	HPA037011

GENE INFORMATION
Gene name	ASTE1 (HGNC Symbol)
Synonyms	HT001
Description	Asteroid homolog 1 (Drosophila) (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q22.1
Chromosome location (bp)	131013875 - 131027649
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000034533 (version 83.38)
Entrez gene	28990
UniProt	Q2TB18 (UniProt - Evidence at protein level)
neXtProt	NX_Q2TB18
Antibodypedia	ASTE1 antibodies

PROTEIN BROWSER

ASTE1-001	ASTE1-003	ASTE1-005	ASTE1-006	ASTE1-007	ASTE1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASTE1-001 ENSP00000264992 ENST00000264992	Q2TB18 [Direct mapping] Protein asteroid homolog 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004518 [nuclease activity] GO:0005515 [protein binding] GO:0006281 [DNA repair] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	679 aa 77.1 kDa	No	0
ASTE1-003 ENSP00000426421 ENST00000514044	D6RG30 [Direct mapping] Asteroid homolog 1 (Drosophila), isoform CRA_c; Protein asteroid homolog 1 Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004518 [nuclease activity] GO:0006281 [DNA repair] GO:0090305 [nucleic acid phosphodiester bond hydrolysis] Show all	704 aa 79.9 kDa	No	0
ASTE1-005 ENSP00000425683 ENST00000505545	D6RJF1 [Direct mapping] Protein asteroid homolog 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 5.8 kDa	No	0
ASTE1-006 ENSP00000427303 ENST00000509060		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		7 aa 0.8 kDa	No	0
ASTE1-007 ENSP00000422851 ENST00000504725	D6R9W5 [Direct mapping] Protein asteroid homolog 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		48 aa 5.6 kDa	No	0
ASTE1-008 ENSP00000423347 ENST00000505290	H0Y982 [Direct mapping] Protein asteroid homolog 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		97 aa 10.9 kDa	No	0