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DAPK2

GENERAL INFORMATION

Gene name

 DAPK2

Gene description

 Death-associated protein kinase 2

Protein class

 Enzymes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (thyroid gland)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (skeletal muscle, small intestine)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (thyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle, small intestine)

GENE INFORMATION

Gene name

 DAPK2 (HGNC Symbol)

Synonyms

 DRP-1, MGC119312

Description

 Death-associated protein kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q22.31

Chromosome location (bp)

 63907036 - 64072033

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000035664 (version 83.38)

Entrez gene

 23604

UniProt

 Q9UIK4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UIK4

Antibodypedia

 DAPK2 antibodies

PROTEIN BROWSER
DAPK2-001
DAPK2-003
DAPK2-007
DAPK2-201
DAPK2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DAPK2-001
ENSP00000408277
ENST00000457488
Q9UIK4 [Direct mapping]
Death-associated protein kinase 2
A0A024R603 [Target identity:100%; Query identity:100%]
Death-associated protein kinase 2, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0010506 [regulation of autophagy]
GO:0031410 [cytoplasmic vesicle]
GO:0034423 [autophagosome lumen]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043276 [anoikis]
GO:0046777 [protein autophosphorylation]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:2000424 [positive regulation of eosinophil chemotaxis]
GO:2001242 [regulation of intrinsic apoptotic signaling pathway]
Show all
 370 aa
42.9 kDa 		No 1
DAPK2-003
ENSP00000484390
ENST00000612884
Q9UIK4 [Direct mapping]
Death-associated protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0010506 [regulation of autophagy]
GO:0031410 [cytoplasmic vesicle]
GO:0034423 [autophagosome lumen]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043276 [anoikis]
GO:0046777 [protein autophosphorylation]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:2000424 [positive regulation of eosinophil chemotaxis]
GO:2001242 [regulation of intrinsic apoptotic signaling pathway]
Show all
 488 aa
55.9 kDa 		No 1
DAPK2-007
ENSP00000452970
ENST00000559306
H0YKW8 [Direct mapping]
Death-associated protein kinase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 81 aa
9.4 kDa 		No 0
DAPK2-201
ENSP00000261891
ENST00000261891
Q9UIK4 [Direct mapping]
Death-associated protein kinase 2
A0A024R603 [Target identity:100%; Query identity:100%]
Death-associated protein kinase 2, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0010506 [regulation of autophagy]
GO:0031410 [cytoplasmic vesicle]
GO:0034423 [autophagosome lumen]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043276 [anoikis]
GO:0046777 [protein autophosphorylation]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:2000424 [positive regulation of eosinophil chemotaxis]
GO:2001242 [regulation of intrinsic apoptotic signaling pathway]
Show all
 370 aa
42.9 kDa 		No 1
DAPK2-202
ENSP00000453235
ENST00000558069
Q9UIK4 [Direct mapping]
Death-associated protein kinase 2
A0A0A6YYK9 [Direct mapping]
Death-associated protein kinase 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0010506 [regulation of autophagy]
GO:0031410 [cytoplasmic vesicle]
GO:0034423 [autophagosome lumen]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043276 [anoikis]
GO:0046777 [protein autophosphorylation]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:2000424 [positive regulation of eosinophil chemotaxis]
GO:2001242 [regulation of intrinsic apoptotic signaling pathway]
Show all
 488 aa
55.9 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.