Fields »
ABOUT
HELP
BLOG
NSMAF

GENERAL INFORMATION

Gene name

 NSMAF

Gene description

 Neutral sphingomyelinase (N-SMase) activation associated factor

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 3 antibodies.
HPA023067 , HPA023148 , HPA023151
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023067
HPA023148
HPA023151

GENE INFORMATION

Gene name

 NSMAF (HGNC Symbol)

Synonyms

 FAN

Description

 Neutral sphingomyelinase (N-SMase) activation associated factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

Chromosome

 8

Cytoband

 q12.1

Chromosome location (bp)

 58583504 - 58659844

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000035681 (version 83.38)

Entrez gene

 8439

UniProt

 Q92636 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92636

Antibodypedia

 NSMAF antibodies

PROTEIN BROWSER
NSMAF-001
NSMAF-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NSMAF-001
ENSP00000038176
ENST00000038176
Q92636 [Direct mapping]
Protein FAN
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006672 [ceramide metabolic process]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0012505 [endomembrane system]
GO:0016197 [endosomal transport]
GO:0019898 [extrinsic component of membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:2000304 [positive regulation of ceramide biosynthetic process]
Show all
 917 aa
104.4 kDa 		No 0
NSMAF-002
ENSP00000411012
ENST00000427130
Q92636 [Direct mapping]
Protein FAN
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006672 [ceramide metabolic process]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0012505 [endomembrane system]
GO:0016197 [endosomal transport]
GO:0016230 [sphingomyelin phosphodiesterase activator activity]
GO:0019898 [extrinsic component of membrane]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043085 [positive regulation of catalytic activity]
GO:2000304 [positive regulation of ceramide biosynthetic process]
Show all
 948 aa
107.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.