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ADSS

GENERAL INFORMATION

Gene name

 ADSS

Gene description

 Adenylosuccinate synthase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with occasional cases of nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA024400
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024400

GENE INFORMATION

Gene name

 ADSS

Synonyms

Description

 Adenylosuccinate synthase (HGNC Symbol)

Entrez gene summary

 This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Nov 2010]

Chromosome

 1

Cytoband

 q44

Chromosome location (bp)

 244408494 - 244452134

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000035687 (version 83.38)

Entrez gene

 159

UniProt

 P30520 (UniProt - Evidence at protein level)

neXtProt

 NX_P30520

Antibodypedia

 ADSS antibodies

PROTEIN BROWSER
ADSS-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADSS-001
ENSP00000355493
ENST00000366535
P30520 [Direct mapping]
Adenylosuccinate synthetase isozyme 2
A0A024R5Q7 [Target identity:100%; Query identity:100%]
Adenylosuccinate synthetase isozyme 2
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Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0002376 [immune system process]
GO:0004019 [adenylosuccinate synthase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006167 [AMP biosynthetic process]
GO:0006531 [aspartate metabolic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0014074 [response to purine-containing compound]
GO:0042301 [phosphate ion binding]
GO:0044208 ['de novo' AMP biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046040 [IMP metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0060359 [response to ammonium ion]
GO:0070062 [extracellular exosome]
GO:0071257 [cellular response to electrical stimulus]
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 456 aa
50.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.