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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADSS
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADSS

Gene description

Adenylosuccinate synthase

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression with occasional cases of nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA024400
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA024400

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of malignant cells displayed moderate cytoplasmic immunoreactivity. A few cases of malignant lymphomas, breast and colorectal cancers were strongly stained.

GENE INFORMATION

Gene name

ADSS

Synonyms

Description

Adenylosuccinate synthase (HGNC Symbol)

Entrez gene summary

This gene encodes the enzyme adenylosuccinate synthetase which catalyzes the first committed step in the conversion of inosine monophosphate to adenosine monophosphate. A pseudogene of this gene is found on chromosome 17.[provided by RefSeq, Nov 2010]

Chromosome

1

Cytoband

q44

Chromosome location (bp)

244408494 - 244452134

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000035687 (version 83.38)

Entrez gene

159

UniProt

P30520 (UniProt - Evidence at protein level)

neXtProt

NX_P30520

Antibodypedia

ADSS antibodies

PROTEIN BROWSER

ADSS-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADSS-001
ENSP00000355493
ENST00000366535
P30520 [Direct mapping]
Adenylosuccinate synthetase isozyme 2
A0A024R5Q7 [Target identity:100%; Query identity:100%]
Adenylosuccinate synthetase isozyme 2
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Enzymes
   ENZYME proteins
   Ligase
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0002376 [immune system process]
GO:0004019 [adenylosuccinate synthase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006167 [AMP biosynthetic process]
GO:0006531 [aspartate metabolic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0014074 [response to purine-containing compound]
GO:0042301 [phosphate ion binding]
GO:0044208 ['de novo' AMP biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046040 [IMP metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0060359 [response to ammonium ion]
GO:0070062 [extracellular exosome]
GO:0071257 [cellular response to electrical stimulus]
Show all
456 aa
50.1 kDa
No 0

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