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USP2

GENERAL INFORMATION

Gene name

 USP2

Gene description

 Ubiquitin specific peptidase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (U-266/70)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA006777 , HPA007222
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006777
HPA007222

GENE INFORMATION

Gene name

 USP2 (HGNC Symbol)

Synonyms

 UBP41

Description

 Ubiquitin specific peptidase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 119355215 - 119381726

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000036672 (version 83.38)

Entrez gene

 9099

UniProt

 O75604 (UniProt - Evidence at protein level)

neXtProt

 NX_O75604

Antibodypedia

 USP2 antibodies

PROTEIN BROWSER
USP2-001
USP2-002
USP2-003
USP2-004
USP2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
USP2-001
ENSP00000260187
ENST00000260187
O75604 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 2
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005938 [cell cortex]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007049 [cell cycle]
GO:0007517 [muscle organ development]
GO:0016579 [protein deubiquitination]
GO:0030332 [cyclin binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032922 [circadian regulation of gene expression]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0042802 [identical protein binding]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045475 [locomotor rhythm]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048512 [circadian behavior]
GO:0048642 [negative regulation of skeletal muscle tissue development]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0050821 [protein stabilization]
GO:0061136 [regulation of proteasomal protein catabolic process]
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 605 aa
68.1 kDa 		No 0
USP2-002
ENSP00000407842
ENST00000455332
O75604 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007049 [cell cycle]
GO:0007517 [muscle organ development]
GO:0016579 [protein deubiquitination]
GO:0030332 [cyclin binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032922 [circadian regulation of gene expression]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045475 [locomotor rhythm]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048512 [circadian behavior]
GO:0050821 [protein stabilization]
GO:0061136 [regulation of proteasomal protein catabolic process]
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 362 aa
41.7 kDa 		No 0
USP2-003
ENSP00000436952
ENST00000525735
O75604 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007049 [cell cycle]
GO:0007517 [muscle organ development]
GO:0016579 [protein deubiquitination]
GO:0030332 [cyclin binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032922 [circadian regulation of gene expression]
GO:0036459 [ubiquitinyl hydrolase activity]
GO:0043153 [entrainment of circadian clock by photoperiod]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045475 [locomotor rhythm]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046872 [metal ion binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048512 [circadian behavior]
GO:0050821 [protein stabilization]
GO:0061136 [regulation of proteasomal protein catabolic process]
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 396 aa
45.2 kDa 		No 0
USP2-004
ENSP00000431857
ENST00000527843
E9PJ34 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 2
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Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 137 aa
14.7 kDa 		No 0
USP2-005
ENSP00000433977
ENST00000531070
E9PSH6 [Direct mapping]
Ubiquitin carboxyl-terminal hydrolase 2
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Predicted intracellular proteins
Show all
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0061136 [regulation of proteasomal protein catabolic process]
Show all
 168 aa
18.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.