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CASR

GENERAL INFORMATION

Gene name

 CASR

Gene description

 Calcium-sensing receptor

Protein class

 Disease related genes
FDA approved drug targets
G-protein coupled receptors
Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (pancreatic cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in a subset of renal tubules, islets of Langerhans and parathyroid gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 2 antibodies.
HPA039686 , HPA050335
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039686
HPA050335

GENE INFORMATION

Gene name

 CASR (HGNC Symbol)

Synonyms

 FHH, GPRC2A, HHC, HHC1, NSHPT

Description

 Calcium-sensing receptor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

Chromosome location (bp)

 122183683 - 122286503

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000036828 (version 83.38)

Entrez gene

 846

UniProt

 P41180 (UniProt - Evidence at protein level)

neXtProt

 NX_P41180

Antibodypedia

 CASR antibodies

PROTEIN BROWSER
CASR-001
CASR-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CASR-001
ENSP00000418685
ENST00000490131
P41180 [Direct mapping]
Extracellular calcium-sensing receptor
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   Family 3 (C) receptors
Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
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GO:0001503 [ossification]
GO:0004435 [phosphatidylinositol phospholipase C activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005513 [detection of calcium ion]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007635 [chemosensory behavior]
GO:0009653 [anatomical structure morphogenesis]
GO:0016021 [integral component of membrane]
GO:0070509 [calcium ion import]
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 1078 aa
120.7 kDa 		Yes 7
CASR-002
ENSP00000420194
ENST00000498619
E7ENE0 [Direct mapping]
Extracellular calcium-sensing receptor
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0001503 [ossification]
GO:0002931 [response to ischemia]
GO:0004930 [G-protein coupled receptor activity]
GO:0005178 [integrin binding]
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006915 [apoptotic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0007254 [JNK cascade]
GO:0008144 [drug binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0010038 [response to metal ion]
GO:0010628 [positive regulation of gene expression]
GO:0014070 [response to organic cyclic compound]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019808 [polyamine binding]
GO:0019901 [protein kinase binding]
GO:0030424 [axon]
GO:0032024 [positive regulation of insulin secretion]
GO:0032781 [positive regulation of ATPase activity]
GO:0035729 [cellular response to hepatocyte growth factor stimulus]
GO:0042311 [vasodilation]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043679 [axon terminus]
GO:0044325 [ion channel binding]
GO:0045907 [positive regulation of vasoconstriction]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0050927 [positive regulation of positive chemotaxis]
GO:0051592 [response to calcium ion]
GO:0051924 [regulation of calcium ion transport]
GO:0060613 [fat pad development]
GO:0071305 [cellular response to vitamin D]
GO:0071333 [cellular response to glucose stimulus]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0071456 [cellular response to hypoxia]
GO:0071774 [response to fibroblast growth factor]
GO:0090280 [positive regulation of calcium ion import]
GO:1901653 [cellular response to peptide]
Show all
 1088 aa
121.8 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.