Fields »
ABOUT
HELP
BLOG
NSUN2

GENERAL INFORMATION

Gene name

 NSUN2

Gene description

 NOP2/Sun RNA methyltransferase family, member 2

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous mainly nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA037896
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037896

GENE INFORMATION

Gene name

 NSUN2 (HGNC Symbol)

Synonyms

 FLJ20303, Misu, MRT5, TRM4

Description

 NOP2/Sun RNA methyltransferase family, member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011]

Chromosome

 5

Cytoband

 p15.31

Chromosome location (bp)

 6599239 - 6633291

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000037474 (version 83.38)

Entrez gene

 54888

UniProt

 Q08J23 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08J23

Antibodypedia

 NSUN2 antibodies

PROTEIN BROWSER
NSUN2-001
NSUN2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NSUN2-001
ENSP00000264670
ENST00000264670
Q08J23 [Direct mapping]
tRNA (cytosine(34)-C(5))-methyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0006400 [tRNA modification]
GO:0007067 [mitotic nuclear division]
GO:0007286 [spermatid development]
GO:0008033 [tRNA processing]
GO:0008168 [methyltransferase activity]
GO:0010467 [gene expression]
GO:0016428 [tRNA (cytosine-5-)-methyltransferase activity]
GO:0030488 [tRNA methylation]
GO:0033313 [meiotic cell cycle checkpoint]
GO:0033391 [chromatoid body]
GO:0044822 [poly(A) RNA binding]
GO:0051301 [cell division]
Show all
 767 aa
86.5 kDa 		No 0
NSUN2-004
ENSP00000420957
ENST00000506139
Q08J23 [Direct mapping]
tRNA (cytosine(34)-C(5))-methyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0006400 [tRNA modification]
GO:0007067 [mitotic nuclear division]
GO:0008033 [tRNA processing]
GO:0008168 [methyltransferase activity]
GO:0010467 [gene expression]
GO:0016428 [tRNA (cytosine-5-)-methyltransferase activity]
GO:0030488 [tRNA methylation]
GO:0044822 [poly(A) RNA binding]
GO:0051301 [cell division]
Show all
 732 aa
82.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.