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Most malignant cells were either negative or displayed weak nuclear and/or cytoplasmic staining. Several cases of breast, prostate and liver cancers expressed moderate staining.
GENE INFORMATION
Gene name
FBXO42 (HGNC Symbol)
Synonyms
Fbx42, KIAA1332
Description
F-box protein 42 (HGNC Symbol)
Entrez gene summary
Members of the F-box protein family, such as FBXO42, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (SKP1A; MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Dec 2010]