Cell atlas - AGA - The Human Protein Atlas

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AGA

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	AGA
Gene description	Aspartylglucosaminidase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	AGA (HGNC Symbol)
Synonyms	ASRG
Description	Aspartylglucosaminidase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. This enzyme is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. Mutations in this gene are associated with the lysosomal storage disease aspartylglycosaminuria that results in progressive neurodegeneration. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing. [provided by RefSeq, Nov 2015]
Chromosome	4
Cytoband	q34.3
Chromosome location (bp)	177430770 - 177442503
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000038002 (version 83.38)
Entrez gene	175
UniProt	P20933 (UniProt - Evidence at protein level)
neXtProt	NX_P20933
Antibodypedia	AGA antibodies

PROTEIN BROWSER

AGA-001	AGA-004	AGA-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGA-001 ENSP00000264595 ENST00000264595	P20933 [Direct mapping] N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase Glycosylasparaginase alpha chain Glycosylasparaginase beta chain Show all	Enzymes ENZYME proteins Hydrolases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003948 [N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005783 [endoplasmic reticulum] GO:0006508 [proteolysis] GO:0006517 [protein deglycosylation] GO:0008233 [peptidase activity] GO:0016787 [hydrolase activity] GO:0043621 [protein self-association] GO:0051604 [protein maturation] GO:0070062 [extracellular exosome] Show all	346 aa 37.2 kDa	Yes	0
AGA-004 ENSP00000421471 ENST00000510635	H0Y8L9 [Direct mapping] N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	138 aa 14.8 kDa	No	0
AGA-006 ENSP00000423798 ENST00000502310	H0Y9C7 [Direct mapping] N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] Show all	155 aa 17.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.