Expression of PI4K2B in cancer - Summary

GENERAL INFORMATION
Gene name	PI4K2B
Gene description	Phosphatidylinositol 4-kinase type 2 beta
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression. Additional membranous expression in intestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA004099
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA004099

GENE INFORMATION
Gene name	PI4K2B (HGNC Symbol)
Synonyms	FLJ11105, PI4KIIB, PIK42B
Description	Phosphatidylinositol 4-kinase type 2 beta (HGNC Symbol)
Entrez gene summary	Phosphatidylinositol 4-kinases (PI4Ks) phosphorylate phosphatidylinositol to generate phosphatidylinositol 4-phosphate (PIP), an immediate precursor of several important signaling and scaffolding molecules. PIP itself may also have direct functional and structural roles. PI4K2B is a primarily cytosolic PI4K that is recruited to membranes, where it stimulates phosphatidylinositol 4,5-bisphosphate synthesis (Wei et al., 2002 [PubMed 12324459]).[supplied by OMIM, Jun 2008]
Chromosome	4
Cytoband	p15.2
Chromosome location (bp)	25233975 - 25279092
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000038210 (version 83.38)
Entrez gene	55300
UniProt	Q8TCG2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TCG2
Antibodypedia	PI4K2B antibodies

PROTEIN BROWSER

PI4K2B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PI4K2B-001 ENSP00000264864 ENST00000264864	Q8TCG2 [Direct mapping] Phosphatidylinositol 4-kinase type 2-beta Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004430 [1-phosphatidylinositol 4-kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0016020 [membrane] GO:0016773 [phosphotransferase activity, alcohol group as acceptor] GO:0044281 [small molecule metabolic process] GO:0046854 [phosphatidylinositol phosphorylation] Show all	481 aa 54.7 kDa	No	0