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VCAN

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GENERAL INFORMATION

Gene name

 VCAN

Gene description

 Versican

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Cell line enhanced (AF22, RPTEC TERT1, U-2197, U-251 MG)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA004726
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, RPTEC TERT1, U-2197, U-251 MG)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA004726 A-431 No staining    
HPA004726 U-2 OS No staining    
HPA004726 U-251 MG Vesicles Intensity

GENE INFORMATION

Gene name

 VCAN (HGNC Symbol)

Synonyms

 CSPG2, PG-M

Description

 Versican (HGNC Symbol)

Entrez gene summary

 This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Chromosome

 5

Cytoband

Chromosome location (bp)

 83471465 - 83582303

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000038427 (version 83.38)

Entrez gene

 1462

UniProt

 P13611 (UniProt - Evidence at protein level)

neXtProt

 NX_P13611

Antibodypedia

 VCAN antibodies

PROTEIN BROWSER
VCAN-001
VCAN-002
VCAN-003
VCAN-005
VCAN-007
VCAN-201
VCAN-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VCAN-001
ENSP00000265077
ENST00000265077
P13611 [Direct mapping]
Versican core protein
A0A024RAQ9 [Target identity:100%; Query identity:100%]
Chondroitin sulfate proteoglycan 2 (Versican), isoform CRA_b
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005540 [hyaluronic acid binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0007275 [multicellular organismal development]
GO:0007417 [central nervous system development]
GO:0007507 [heart development]
GO:0008037 [cell recognition]
GO:0008347 [glial cell migration]
GO:0016020 [membrane]
GO:0019903 [protein phosphatase binding]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0030246 [carbohydrate binding]
GO:0031012 [extracellular matrix]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
Show all
 3396 aa
372.8 kDa 		Yes 0
VCAN-002
ENSP00000425959
ENST00000512590
E9PF17 [Direct mapping]
Versican core protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0007155 [cell adhesion]
GO:0007417 [central nervous system development]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 1594 aa
176.8 kDa 		No 0
VCAN-003
ENSP00000426251
ENST00000513960
D6RGZ6 [Direct mapping]
Versican core protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0007155 [cell adhesion]
GO:0007417 [central nervous system development]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 1240 aa
135.7 kDa 		Yes 0
VCAN-005
ENSP00000421362
ENST00000502527
P13611 [Direct mapping]
Versican core protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005540 [hyaluronic acid binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0007275 [multicellular organismal development]
GO:0007417 [central nervous system development]
GO:0008037 [cell recognition]
GO:0008347 [glial cell migration]
GO:0016020 [membrane]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0030246 [carbohydrate binding]
GO:0031012 [extracellular matrix]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
Show all
 655 aa
74.3 kDa 		Yes 0
VCAN-007
ENSP00000426715
ENST00000513984
Q86W61 [Direct mapping]
VCAN protein; Versican core protein
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0005515 [protein binding]
GO:0005540 [hyaluronic acid binding]
GO:0007155 [cell adhesion]
GO:0007417 [central nervous system development]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 354 aa
39.3 kDa 		Yes 0
VCAN-201
ENSP00000342768
ENST00000342785
P13611 [Direct mapping]
Versican core protein
A0A024RAP3 [Target identity:100%; Query identity:100%]
Chondroitin sulfate proteoglycan 2 (Versican), isoform CRA_a
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005540 [hyaluronic acid binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0007275 [multicellular organismal development]
GO:0007417 [central nervous system development]
GO:0008037 [cell recognition]
GO:0008347 [glial cell migration]
GO:0016020 [membrane]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0030246 [carbohydrate binding]
GO:0031012 [extracellular matrix]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
Show all
 1642 aa
182.1 kDa 		Yes 0
VCAN-202
ENSP00000340062
ENST00000343200
P13611 [Direct mapping]
Versican core protein
A0A024RAL1 [Target identity:100%; Query identity:100%]
Chondroitin sulfate proteoglycan 2 (Versican), isoform CRA_c
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0001649 [osteoblast differentiation]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005539 [glycosaminoglycan binding]
GO:0005540 [hyaluronic acid binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0005975 [carbohydrate metabolic process]
GO:0007155 [cell adhesion]
GO:0007275 [multicellular organismal development]
GO:0007417 [central nervous system development]
GO:0008037 [cell recognition]
GO:0008347 [glial cell migration]
GO:0016020 [membrane]
GO:0030198 [extracellular matrix organization]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030204 [chondroitin sulfate metabolic process]
GO:0030206 [chondroitin sulfate biosynthetic process]
GO:0030207 [chondroitin sulfate catabolic process]
GO:0030208 [dermatan sulfate biosynthetic process]
GO:0030246 [carbohydrate binding]
GO:0031012 [extracellular matrix]
GO:0043202 [lysosomal lumen]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044281 [small molecule metabolic process]
Show all
 2409 aa
265 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.