Expression of PQLC2 in cancer - Summary - The Human Protein Atlas

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PQLC2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PQLC2
Gene description	PQ loop repeat containing 2
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA057810
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and endometrial cancer (favourable).
Liver cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA057810

GENE INFORMATION
Gene name	PQLC2 (HGNC Symbol)
Synonyms	FLJ20320
Description	PQ loop repeat containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p36.13
Chromosome location (bp)	19312326 - 19329300
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000040487 (version 83.38)
Entrez gene	54896
UniProt	Q6ZP29 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZP29
Antibodypedia	PQLC2 antibodies

PROTEIN BROWSER

PQLC2-001	PQLC2-002	PQLC2-006	PQLC2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PQLC2-001 ENSP00000364297 ENST00000375155	Q6ZP29 [Direct mapping] Lysosomal amino acid transporter 1 homolog A0A024RA97 [Target identity:100%; Query identity:100%] PQ loop repeat containing 2, isoform CRA_c Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005765 [lysosomal membrane] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015181 [arginine transmembrane transporter activity] GO:0015189 [L-lysine transmembrane transporter activity] GO:0015809 [arginine transport] GO:0015819 [lysine transport] GO:0031301 [integral component of organelle membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0080144 [amino acid homeostasis] GO:1903401 [L-lysine transmembrane transport] GO:1903826 [arginine transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	291 aa 31.9 kDa	No	6
PQLC2-002 ENSP00000364295 ENST00000375153	Q6ZP29 [Direct mapping] Lysosomal amino acid transporter 1 homolog A0A024RA97 [Target identity:100%; Query identity:100%] PQ loop repeat containing 2, isoform CRA_c Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005765 [lysosomal membrane] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015181 [arginine transmembrane transporter activity] GO:0015189 [L-lysine transmembrane transporter activity] GO:0015809 [arginine transport] GO:0015819 [lysine transport] GO:0031301 [integral component of organelle membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0080144 [amino acid homeostasis] GO:1903401 [L-lysine transmembrane transport] GO:1903826 [arginine transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	291 aa 31.9 kDa	No	6
PQLC2-006 ENSP00000383395 ENST00000400548	Q6ZP29 [Direct mapping] Lysosomal amino acid transporter 1 homolog A0A024RAA1 [Target identity:100%; Query identity:100%] PQ loop repeat containing 2, isoform CRA_b Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005765 [lysosomal membrane] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015181 [arginine transmembrane transporter activity] GO:0015189 [L-lysine transmembrane transporter activity] GO:0015809 [arginine transport] GO:0015819 [lysine transport] GO:0031301 [integral component of organelle membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0080144 [amino acid homeostasis] GO:1903401 [L-lysine transmembrane transport] GO:1903826 [arginine transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	226 aa 24.8 kDa	No	5
PQLC2-007 ENSP00000404701 ENST00000432465	A2A2E6 [Direct mapping] Lysosomal amino acid transporter 1 homolog Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	127 aa 13.9 kDa	No	3

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The Human Protein Atlas

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