Cell atlas - PHF23 - The Human Protein Atlas

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PHF23

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS siRNA MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PHF23
Gene description	PHD finger protein 23
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.
Mouse	Localized to the Cytosol in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA052410
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA052410	HeLa	Nucleoplasm
HPA052410	MCF7	Nucleoplasm
HPA052410	U-2 OS	Nucleoplasm

siRNA VALIDATION

Antibody

HPA052410

siRNA validation

Validated: Significant downregulation > 25% by one siRNA.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 1

RFI

68%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail 10x	Thumbnail 40x	Antibody	Sample	Cell line
		HPA052410	siRNA 1	U-2 OS
		HPA052410	scrambled	U-2 OS

MOUSE CELLS

Main location

Cytosol

Additional location

Nucleoplasm

Mouse gene

ENSMUSG00000018572 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA052410	NIH 3T3	Nucleoplasm
	HPA052410	NIH 3T3	Cytosol

GENE INFORMATION
Gene name	PHF23 (HGNC Symbol)
Synonyms	FLJ16355, MGC2941
Description	PHD finger protein 23 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7235028 - 7239722
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000040633 (version 83.38)
Entrez gene	79142
UniProt	Q9BUL5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BUL5
Antibodypedia	PHF23 antibodies

PROTEIN BROWSER

PHF23-001	PHF23-002	PHF23-003	PHF23-005	PHF23-006	PHF23-007	PHF23-008	PHF23-009	PHF23-010	PHF23-013	PHF23-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHF23-001 ENSP00000322579 ENST00000320316	Q9BUL5 [Direct mapping] PHD finger protein 23 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006914 [autophagy] GO:0008270 [zinc ion binding] GO:0031398 [positive regulation of protein ubiquitination] GO:1901097 [negative regulation of autophagosome maturation] GO:1902902 [negative regulation of autophagosome assembly] Show all	403 aa 43.8 kDa	No	0
PHF23-002 ENSP00000458953 ENST00000576955	I3L1N0 [Direct mapping] PHD finger protein 23; PHD finger protein 23, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	273 aa 29.7 kDa	No	0
PHF23-003 ENSP00000460738 ENST00000571362	Q9BUL5 [Direct mapping] PHD finger protein 23 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006914 [autophagy] GO:0008270 [zinc ion binding] GO:0031398 [positive regulation of protein ubiquitination] GO:1901097 [negative regulation of autophagosome maturation] GO:1902902 [negative regulation of autophagosome assembly] Show all	336 aa 36.7 kDa	No	0
PHF23-005 ENSP00000414607 ENST00000454255	Q9BUL5 [Direct mapping] PHD finger protein 23 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006914 [autophagy] GO:0008270 [zinc ion binding] GO:0031398 [positive regulation of protein ubiquitination] GO:1901097 [negative regulation of autophagosome maturation] GO:1902902 [negative regulation of autophagosome assembly] Show all	399 aa 43.4 kDa	No	0
PHF23-006 ENSP00000461442 ENST00000573826	I3L4Q4 [Direct mapping] PHD finger protein 23 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		203 aa 21.9 kDa	No	0
PHF23-007 ENSP00000459983 ENST00000574323	I3L2W6 [Direct mapping] PHD finger protein 23 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.4 kDa	No	0
PHF23-008 ENSP00000459904 ENST00000574407		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		6 aa 0.7 kDa	No	0
PHF23-009 ENSP00000460876 ENST00000572789	I3L410 [Direct mapping] PHD finger protein 23 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		201 aa 21.6 kDa	No	0
PHF23-010 ENSP00000458401 ENST00000574236	I3L0X3 [Direct mapping] PHD finger protein 23 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		36 aa 3.8 kDa	No	0
PHF23-013 ENSP00000458416 ENST00000570899	I3L0Y2 [Direct mapping] PHD finger protein 23 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		186 aa 20.4 kDa	No	0
PHF23-201 ENSP00000479592 ENST00000613632	A0A087WVQ2 [Direct mapping] PHD finger protein 23 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		158 aa 17.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.