Fields »
ABOUT
HELP
BLOG
CDH10

GENERAL INFORMATION

Gene name

 CDH10

Gene description

 Cadherin 10, type 2 (T2-cadherin)

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (glioma, prostate cancer)
HPA (cell line):Cell line enhanced (AF22, U-138 MG)
HPA (normal tissue):Group enriched (cerebral cortex, prostate)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA010651
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (glioma, prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA010651

GENE INFORMATION

Gene name

 CDH10

Synonyms

Description

 Cadherin 10, type 2 (T2-cadherin) (HGNC Symbol)

Entrez gene summary

 This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. [provided by RefSeq, Nov 2015]

Chromosome

 5

Cytoband

Chromosome location (bp)

 24487100 - 24644978

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000040731 (version 83.38)

Entrez gene

 1008

UniProt

 Q9Y6N8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6N8

Antibodypedia

 CDH10 antibodies

PROTEIN BROWSER
CDH10-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDH10-001
ENSP00000264463
ENST00000264463
Q9Y6N8 [Direct mapping]
Cadherin-10
X5D8X5 [Target identity:100%; Query identity:100%]
Cadherin 10 type 2 isoform A; Cadherin 10, type 2 (T2-cadherin)
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0045216 [cell-cell junction organization]
Show all
 788 aa
88.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.