Cell atlas - INPP4A - The Human Protein Atlas

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INPP4A

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nucleus

Human cell
	Nuclear membrane
	Nucleoplasm

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GENERAL INFORMATION
Gene name	INPP4A
Gene description	Inositol polyphosphate-4-phosphatase type I A
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nuclear membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nuclear membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA001628
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nuclear membrane.

Main location

Nucleus (approved), Nuclear membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001628	RT4	No staining
	HPA001628	SH-SY5Y	Nucleus
	HPA001628	SH-SY5Y	Nuclear membrane
	HPA001628	U-2 OS	Nucleus
	HPA001628	U-2 OS	Nuclear membrane

GENE INFORMATION
Gene name	INPP4A (HGNC Symbol)
Synonyms	INPP4
Description	Inositol polyphosphate-4-phosphatase type I A (HGNC Symbol)
Entrez gene summary	This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008]
Chromosome	2
Cytoband	q11.2
Chromosome location (bp)	98444854 - 98594390
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000040933 (version 83.38)
Entrez gene	3631
UniProt	Q96PE3 (UniProt - Evidence at protein level)
neXtProt	NX_Q96PE3
Antibodypedia	INPP4A antibodies

PROTEIN BROWSER

INPP4A-001	INPP4A-002	INPP4A-003	INPP4A-004	INPP4A-009	INPP4A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INPP4A-001 ENSP00000386704 ENST00000409016	Q96PE3 [Direct mapping] Type I inositol 3,4-bisphosphate 4-phosphatase Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007165 [signal transduction] GO:0016311 [dephosphorylation] GO:0016316 [phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity] GO:0034597 [phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity] GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] Show all	938 aa 105.7 kDa	No	0
INPP4A-002 ENSP00000387294 ENST00000409540	Q96PE3 [Direct mapping] Type I inositol 3,4-bisphosphate 4-phosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007165 [signal transduction] GO:0016311 [dephosphorylation] GO:0016316 [phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity] GO:0034597 [phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity] GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] Show all	954 aa 107.3 kDa	No	2
INPP4A-003 ENSP00000386329 ENST00000409463	B8ZZB2 [Direct mapping] Type I inositol 3,4-bisphosphate 4-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		306 aa 34.1 kDa	No	0
INPP4A-004 ENSP00000386777 ENST00000409851	Q96PE3 [Direct mapping] Type I inositol 3,4-bisphosphate 4-phosphatase Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007165 [signal transduction] GO:0016311 [dephosphorylation] GO:0016316 [phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity] GO:0034597 [phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity] GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] Show all	972 aa 109.3 kDa	No	0
INPP4A-009 ENSP00000427722 ENST00000523221	Q96PE3 [Direct mapping] Type I inositol 3,4-bisphosphate 4-phosphatase Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007165 [signal transduction] GO:0016311 [dephosphorylation] GO:0016316 [phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity] GO:0034597 [phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity] GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] Show all	977 aa 110 kDa	No	0
INPP4A-201 ENSP00000074304 ENST00000074304	Q96PE3 [Direct mapping] Type I inositol 3,4-bisphosphate 4-phosphatase Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007165 [signal transduction] GO:0016311 [dephosphorylation] GO:0016316 [phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity] GO:0034597 [phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity] GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] Show all	977 aa 110 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.