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PSMA4

GENERAL INFORMATION

Gene name

 PSMA4

Gene description

 Proteasome subunit alpha 4

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA055466 , HPA060613 , CAB004973
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA055466
HPA060613
CAB004973

GENE INFORMATION

Gene name

 PSMA4 (HGNC Symbol)

Synonyms

 HC9, HsT17706

Description

 Proteasome subunit alpha 4 (HGNC Symbol)

Entrez gene summary

 The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q25.1

Chromosome location (bp)

 78540405 - 78552419

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000041357 (version 83.38)

Entrez gene

 5685

UniProt

 P25789 (UniProt - Evidence at protein level)

neXtProt

 NX_P25789

Antibodypedia

 PSMA4 antibodies

PROTEIN BROWSER
«
PSMA4-001
PSMA4-004
PSMA4-006
PSMA4-009
PSMA4-012
PSMA4-014
PSMA4-015
PSMA4-016
PSMA4-017
PSMA4-018
PSMA4-019
PSMA4-020
PSMA4-021
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PSMA4-001
ENSP00000044462
ENST00000044462
P25789 [Direct mapping]
Proteasome subunit alpha type-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Threonine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005839 [proteasome core complex]
GO:0005886 [plasma membrane]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 261 aa
29.5 kDa 		No 0
PSMA4-004
ENSP00000402118
ENST00000413382
P25789 [Direct mapping]
Proteasome subunit alpha type-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Threonine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005839 [proteasome core complex]
GO:0005886 [plasma membrane]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 190 aa
21.4 kDa 		No 0
PSMA4-006
ENSP00000453887
ENST00000559082
P25789 [Direct mapping]
Proteasome subunit alpha type-4
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Threonine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0000502 [proteasome complex]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0002479 [antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent]
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005839 [proteasome core complex]
GO:0005886 [plasma membrane]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006521 [regulation of cellular amino acid metabolic process]
GO:0006595 [polyamine metabolic process]
GO:0006915 [apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010467 [gene expression]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0012501 [programmed cell death]
GO:0016032 [viral process]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0038061 [NIK/NF-kappaB signaling]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042590 [antigen processing and presentation of exogenous peptide antigen via MHC class I]
GO:0042981 [regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043488 [regulation of mRNA stability]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
Show all
 261 aa
29.5 kDa 		No 0
PSMA4-009
ENSP00000453829
ENST00000560217
H0YN18 [Direct mapping]
Proteasome subunit alpha type-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005839 [proteasome core complex]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 230 aa
26.3 kDa 		No 0
PSMA4-012
ENSP00000453080
ENST00000560737
H0YL69 [Direct mapping]
Proteasome subunit alpha type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005839 [proteasome core complex]
GO:0005886 [plasma membrane]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 236 aa
26.4 kDa 		No 0
PSMA4-014
ENSP00000452936
ENST00000559948
H0YKT8 [Direct mapping]
Proteasome subunit beta type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005839 [proteasome core complex]
GO:0005886 [plasma membrane]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 182 aa
20.1 kDa 		No 0
PSMA4-015
ENSP00000453802
ENST00000559365
H0YMZ1 [Direct mapping]
Proteasome subunit alpha type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005839 [proteasome core complex]
GO:0005886 [plasma membrane]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 221 aa
24.6 kDa 		No 0
PSMA4-016
ENSP00000453523
ENST00000559437
H0YMA1 [Direct mapping]
Proteasome subunit alpha type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005839 [proteasome core complex]
GO:0005886 [plasma membrane]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 209 aa
23.3 kDa 		No 0
PSMA4-017
ENSP00000453323
ENST00000558341
H0YLS6 [Direct mapping]
Proteasome subunit alpha type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005839 [proteasome core complex]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 125 aa
13.9 kDa 		No 0
PSMA4-018
ENSP00000453621
ENST00000559146
H0YMI6 [Direct mapping]
Proteasome subunit alpha type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005839 [proteasome core complex]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 183 aa
20.5 kDa 		No 0
PSMA4-019
ENSP00000453145
ENST00000558281
H0YLC2 [Direct mapping]
Proteasome subunit alpha type
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005839 [proteasome core complex]
GO:0005886 [plasma membrane]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0019773 [proteasome core complex, alpha-subunit complex]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 174 aa
19.7 kDa 		No 0
PSMA4-020
ENSP00000452917
ENST00000559154
H0YKS0 [Direct mapping]
Proteasome subunit alpha type-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005839 [proteasome core complex]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 122 aa
13.6 kDa 		No 0
PSMA4-021
ENSP00000453758
ENST00000558094
H0YMV3 [Direct mapping]
Proteasome subunit alpha type-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004298 [threonine-type endopeptidase activity]
GO:0005839 [proteasome core complex]
GO:0010499 [proteasomal ubiquitin-independent protein catabolic process]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
Show all
 86 aa
9.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.