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PARP3

GENERAL INFORMATION

Gene name

 PARP3

Gene description

 Poly (ADP-ribose) polymerase family, member 3

Protein class

 Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA067657
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (favourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA067657

GENE INFORMATION

Gene name

 PARP3 (HGNC Symbol)

Synonyms

 ADPRT3, ADPRTL3, hPARP-3, IRT1, pADPRT-3

Description

 Poly (ADP-ribose) polymerase family, member 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p21.2

Chromosome location (bp)

 51942345 - 51948867

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000041880 (version 83.38)

Entrez gene

 10039

UniProt

 Q9Y6F1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6F1

Antibodypedia

 PARP3 antibodies

PROTEIN BROWSER
PARP3-001
PARP3-002
PARP3-005
PARP3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PARP3-001
ENSP00000381740
ENST00000398755
Q9Y6F1 [Direct mapping]
Poly [ADP-ribose] polymerase 3
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Enzymes
   ENZYME proteins
   Transferases
   Phobius predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
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GO:0000723 [telomere maintenance]
GO:0003824 [catalytic activity]
GO:0003950 [NAD+ ADP-ribosyltransferase activity]
GO:0005634 [nucleus]
GO:0005814 [centriole]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006471 [protein ADP-ribosylation]
GO:0035861 [site of double-strand break]
GO:0051106 [positive regulation of DNA ligation]
GO:0060236 [regulation of mitotic spindle organization]
GO:1990166 [protein localization to site of double-strand break]
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 540 aa
60.9 kDa 		No 0
PARP3-002
ENSP00000395951
ENST00000417220
A0A024R2X5 [Direct mapping]
Poly (ADP-ribose) polymerase family, member 3, isoform CRA_a; Poly [ADP-ribose] polymerase 3
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   Phobius predicted membrane proteins
Predicted intracellular proteins
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GO:0003950 [NAD+ ADP-ribosyltransferase activity]
GO:0006471 [protein ADP-ribosylation]
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 533 aa
60.1 kDa 		No 0
PARP3-005
ENSP00000417625
ENST00000498510
C9J9C7 [Direct mapping]
Poly [ADP-ribose] polymerase 3
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Predicted intracellular proteins
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GO:0003950 [NAD+ ADP-ribosyltransferase activity]
GO:0006471 [protein ADP-ribosylation]
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 332 aa
37.8 kDa 		No 0
PARP3-201
ENSP00000401511
ENST00000431474
A0A024R2X5 [Direct mapping]
Poly (ADP-ribose) polymerase family, member 3, isoform CRA_a; Poly [ADP-ribose] polymerase 3
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   Phobius predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0003950 [NAD+ ADP-ribosyltransferase activity]
GO:0006471 [protein ADP-ribosylation]
Show all
 533 aa
60.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.