Cell atlas - AIFM2 - The Human Protein Atlas

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AIFM2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	AIFM2
Gene description	Apoptosis-inducing factor, mitochondrion-associated, 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA028961
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028961	A549	No staining
	HPA028961	Hep G2	Cytosol	Intensity
	HPA028961	U-2 OS	No staining

GENE INFORMATION
Gene name	AIFM2 (HGNC Symbol)
Synonyms	AMID, FLJ14497, PRG3
Description	Apoptosis-inducing factor, mitochondrion-associated, 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]
Chromosome	10
Cytoband	q22.1
Chromosome location (bp)	70098223 - 70132934
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000042286 (version 83.38)
Entrez gene	84883
UniProt	Q9BRQ8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BRQ8
Antibodypedia	AIFM2 antibodies

PROTEIN BROWSER

AIFM2-001	AIFM2-002	AIFM2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AIFM2-001 ENSP00000312370 ENST00000307864	Q9BRQ8 [Direct mapping] Apoptosis-inducing factor 2 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004174 [electron-transferring-flavoprotein dehydrogenase activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0008637 [apoptotic mitochondrial changes] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0043065 [positive regulation of apoptotic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	373 aa 40.5 kDa	No	0
AIFM2-002 ENSP00000362345 ENST00000373248	Q9BRQ8 [Direct mapping] Apoptosis-inducing factor 2 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004174 [electron-transferring-flavoprotein dehydrogenase activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0008637 [apoptotic mitochondrial changes] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0043065 [positive regulation of apoptotic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	373 aa 40.5 kDa	No	0
AIFM2-201 ENSP00000478931 ENST00000613322	Q9BRQ8 [Direct mapping] Apoptosis-inducing factor 2 Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004174 [electron-transferring-flavoprotein dehydrogenase activity] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0005811 [lipid particle] GO:0005829 [cytosol] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0008637 [apoptotic mitochondrial changes] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0043065 [positive regulation of apoptotic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	373 aa 40.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.