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CAPG

GENERAL INFORMATION

Gene name

 CAPG

Gene description

 Capping protein (actin filament), gelsolin-like

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (CAPAN-2, HMC-1)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in lung macrophages, epidermal Langerhans cells and macrophages in lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA018843 , HPA019080 , HPA019092
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA018843
HPA019080
HPA019092

GENE INFORMATION

Gene name

 CAPG (HGNC Symbol)

Synonyms

 AFCP, MCP

Description

 Capping protein (actin filament), gelsolin-like (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 85394748 - 85418432

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000042493 (version 83.38)

Entrez gene

 822

UniProt

 P40121 (UniProt - Evidence at protein level)

neXtProt

 NX_P40121

Antibodypedia

 CAPG antibodies

PROTEIN BROWSER
CAPG-001
CAPG-002
CAPG-003
CAPG-004
CAPG-005
CAPG-008
CAPG-011
CAPG-012
CAPG-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAPG-001
ENSP00000263867
ENST00000263867
P40121 [Direct mapping]
Macrophage-capping protein
V9HW69 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 66
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0006461 [protein complex assembly]
GO:0008290 [F-actin capping protein complex]
GO:0019904 [protein domain specific binding]
GO:0030031 [cell projection assembly]
GO:0032403 [protein complex binding]
GO:0042470 [melanosome]
GO:0051016 [barbed-end actin filament capping]
GO:0070062 [extracellular exosome]
GO:0072686 [mitotic spindle]
GO:0090543 [Flemming body]
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 348 aa
38.5 kDa 		No 0
CAPG-002
ENSP00000386965
ENST00000409724
P40121 [Direct mapping]
Macrophage-capping protein
V9HW69 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 66
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0006461 [protein complex assembly]
GO:0008290 [F-actin capping protein complex]
GO:0019904 [protein domain specific binding]
GO:0032403 [protein complex binding]
GO:0042470 [melanosome]
GO:0051016 [barbed-end actin filament capping]
GO:0070062 [extracellular exosome]
GO:0072686 [mitotic spindle]
GO:0090543 [Flemming body]
Show all
 348 aa
38.5 kDa 		No 0
CAPG-003
ENSP00000386315
ENST00000409670
P40121 [Direct mapping]
Macrophage-capping protein
V9HW69 [Target identity:100%; Query identity:100%]
Epididymis secretory protein Li 66
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0006461 [protein complex assembly]
GO:0008290 [F-actin capping protein complex]
GO:0019904 [protein domain specific binding]
GO:0032403 [protein complex binding]
GO:0042470 [melanosome]
GO:0051016 [barbed-end actin filament capping]
GO:0070062 [extracellular exosome]
GO:0072686 [mitotic spindle]
GO:0090543 [Flemming body]
Show all
 348 aa
38.5 kDa 		No 0
CAPG-004
ENSP00000387063
ENST00000409921
P40121 [Direct mapping]
Macrophage-capping protein
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005814 [centriole]
GO:0006461 [protein complex assembly]
GO:0008290 [F-actin capping protein complex]
GO:0019904 [protein domain specific binding]
GO:0032403 [protein complex binding]
GO:0042470 [melanosome]
GO:0051016 [barbed-end actin filament capping]
GO:0070062 [extracellular exosome]
GO:0072686 [mitotic spindle]
GO:0090543 [Flemming body]
Show all
 333 aa
36.9 kDa 		No 0
CAPG-005
ENSP00000391923
ENST00000439385
E7ENU9 [Direct mapping]
Macrophage-capping protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0051016 [barbed-end actin filament capping]
Show all
 253 aa
27.8 kDa 		No 0
CAPG-008
ENSP00000398232
ENST00000447219
E7ENU9 [Direct mapping]
Macrophage-capping protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0051016 [barbed-end actin filament capping]
Show all
 253 aa
27.8 kDa 		No 0
CAPG-011
ENSP00000403330
ENST00000449030
E7ENU9 [Direct mapping]
Macrophage-capping protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0051016 [barbed-end actin filament capping]
Show all
 253 aa
27.8 kDa 		No 0
CAPG-012
ENSP00000386596
ENST00000409275
B8ZZL6 [Direct mapping]
Macrophage-capping protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005634 [nucleus]
GO:0051016 [barbed-end actin filament capping]
Show all
 218 aa
24.1 kDa 		No 0
CAPG-016
ENSP00000397381
ENST00000453973
H7C0X8 [Direct mapping]
Macrophage-capping protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0051016 [barbed-end actin filament capping]
Show all
 103 aa
11.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.