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AP2S1

GENERAL INFORMATION

Gene name

 AP2S1

Gene description

 Adaptor-related protein complex 2, sigma 1 subunit

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 AP2S1 (HGNC Symbol)

Synonyms

 CLAPS2, FBH3, FBHOk, HHC3

Description

 Adaptor-related protein complex 2, sigma 1 subunit (HGNC Symbol)

Entrez gene summary

 One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 46838136 - 46850992

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000042753 (version 83.38)

Entrez gene

 1175

UniProt

 P53680 (UniProt - Evidence at protein level)

neXtProt

 NX_P53680

Antibodypedia

 AP2S1 antibodies

PROTEIN BROWSER
AP2S1-001
AP2S1-002
AP2S1-003
AP2S1-004
AP2S1-005
AP2S1-007
AP2S1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AP2S1-001
ENSP00000263270
ENST00000263270
P53680 [Direct mapping]
AP-2 complex subunit sigma
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016192 [vesicle-mediated transport]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030100 [regulation of endocytosis]
GO:0030117 [membrane coat]
GO:0030122 [AP-2 adaptor complex]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0035615 [clathrin adaptor activity]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048268 [clathrin coat assembly]
GO:0050690 [regulation of defense response to virus by virus]
GO:0072583 [clathrin-mediated endocytosis]
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 142 aa
17 kDa 		No 0
AP2S1-002
ENSP00000470235
ENST00000597020
M0QZ21 [Direct mapping]
AP-2 complex subunit sigma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 122 aa
14.6 kDa 		No 0
AP2S1-003
ENSP00000470898
ENST00000601649
P53680 [Direct mapping]
AP-2 complex subunit sigma
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030100 [regulation of endocytosis]
GO:0030122 [AP-2 adaptor complex]
GO:0030666 [endocytic vesicle membrane]
GO:0030669 [clathrin-coated endocytic vesicle membrane]
GO:0035615 [clathrin adaptor activity]
GO:0036020 [endolysosome membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048268 [clathrin coat assembly]
GO:0050690 [regulation of defense response to virus by virus]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 104 aa
12.4 kDa 		No 0
AP2S1-004
ENSP00000471340
ENST00000599990
M0R0N4 [Direct mapping]
AP-2 complex subunit sigma
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 144 aa
17.3 kDa 		No 0
AP2S1-005
ENSP00000470176
ENST00000601498
M0QYZ2 [Direct mapping]
AP-2 complex subunit sigma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 158 aa
18.9 kDa 		No 0
AP2S1-007
ENSP00000263271
ENST00000352203
X6R390 [Direct mapping]
AP-2 complex subunit sigma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 156 aa
18.4 kDa 		No 0
AP2S1-008
ENSP00000472080
ENST00000593442
M0R1S0 [Direct mapping]
AP-2 complex subunit sigma
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006810 [transport]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0015031 [protein transport]
GO:0016192 [vesicle-mediated transport]
GO:0030117 [membrane coat]
Show all
 92 aa
11 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.