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ADAM28
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene name

ADAM28

Gene description

ADAM metallopeptidase domain 28

Protein class

Enzymes
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (CAPAN-2)
HPA (normal tissue):Tissue enhanced (epididymis)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

Pending cancer tissue analysis.

PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis


STAINING SUMMARY

 

GENE INFORMATION

Gene name

ADAM28 (HGNC Symbol)

Synonyms

ADAM23, eMDCII, MDC-Lm, MDC-Ls

Description

ADAM metallopeptidase domain 28 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Chromosome

8

Cytoband

p21.2

Chromosome location (bp)

24294040 - 24359018

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000042980 (version 83.38)

Entrez gene

10863

UniProt

Q9UKQ2 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9UKQ2

Antibodypedia

ADAM28 antibodies

PROTEIN BROWSER

ADAM28-001
ADAM28-002
ADAM28-009
ADAM28-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAM28-001
ENSP00000265769
ENST00000265769
Q9UKQ2 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 28
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007283 [spermatogenesis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
Show all
775 aa
87.1 kDa
Yes 1
ADAM28-002
ENSP00000393699
ENST00000437154
Q9UKQ2 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 28
Show all
Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0006508 [proteolysis]
GO:0007283 [spermatogenesis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
Show all
540 aa
61.2 kDa
Yes 0
ADAM28-009
ENSP00000430094
ENST00000518326
H0YBQ8 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 28
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0006508 [proteolysis]
GO:0016021 [integral component of membrane]
Show all
174 aa
19.2 kDa
No 2
ADAM28-011
ENSP00000429484
ENST00000521629
H0YBG8 [Direct mapping]
Disintegrin and metalloproteinase domain-containing protein 28
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0006508 [proteolysis]
GO:0016021 [integral component of membrane]
Show all
387 aa
42.7 kDa
No 1

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