Expression of JADE2 in cancer - Summary - The Human Protein Atlas

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JADE2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	JADE2
Gene description	Jade family PHD finger 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Luminal membrane expression in a few tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA025959
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA025959

GENE INFORMATION
Gene name	JADE2 (HGNC Symbol)
Synonyms	JADE-2, KIAA0239, PHF15
Description	Jade family PHD finger 2 (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q31.1
Chromosome location (bp)	134524312 - 134583230
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000043143 (version 83.38)
Entrez gene	23338
UniProt	Q9NQC1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NQC1
Antibodypedia	JADE2 antibodies

PROTEIN BROWSER

JADE2-001	JADE2-002	JADE2-003	JADE2-007	JADE2-008	JADE2-011	JADE2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
JADE2-001 ENSP00000354425 ENST00000361895	A0A0C4DFT8 [Direct mapping] Protein Jade-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	791 aa 87.5 kDa	No	0
JADE2-002 ENSP00000378451 ENST00000395003	Q9NQC1 [Direct mapping] Protein Jade-2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000123 [histone acetyltransferase complex] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] GO:0043966 [histone H3 acetylation] GO:0043981 [histone H4-K5 acetylation] GO:0043982 [histone H4-K8 acetylation] GO:0043983 [histone H4-K12 acetylation] GO:0070062 [extracellular exosome] Show all	790 aa 87.5 kDa	No	0
JADE2-003 ENSP00000282605 ENST00000282605	G3XAA4 [Direct mapping] PHD finger protein 15, isoform CRA_d; Protein Jade-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0008270 [zinc ion binding] GO:0060395 [SMAD protein signal transduction] Show all	834 aa 92.1 kDa	No	0
JADE2-007 ENSP00000384671 ENST00000402835	B5MBX1 [Direct mapping] Protein Jade-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	509 aa 57.4 kDa	No	0
JADE2-008 ENSP00000406189 ENST00000431355	C9J929 [Direct mapping] Protein Jade-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	255 aa 28.5 kDa	No	0
JADE2-011 ENSP00000422991 ENST00000512386	D6R9B8 [Direct mapping] Protein Jade-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 16.6 kDa	No	0
JADE2-201 ENSP00000483173 ENST00000612830	A0A087X085 [Direct mapping] PHD finger protein 15, isoform CRA_c; Protein Jade-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		246 aa 25.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.