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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ADRB1
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ADRB1

Gene description

Adrenoceptor beta 1

Protein class

FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (placenta)
GTEx:Tissue enhanced (heart muscle, lung)
FANTOM5:Tissue enhanced (heart muscle, placenta)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in heart myocytes, glial cells and a subset of placental trophoblastic cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA067972
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, lung)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (heart muscle, placenta)

GENE INFORMATION

Gene name

ADRB1 (HGNC Symbol)

Synonyms

ADRB1R

Description

Adrenoceptor beta 1 (HGNC Symbol)

Entrez gene summary

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q25.3

Chromosome location (bp)

114044056 - 114046908

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000043591 (version 83.38)

Entrez gene

153

UniProt

P08588 (UniProt - Evidence at protein level)

neXtProt

NX_P08588

Antibodypedia

ADRB1 antibodies

PROTEIN BROWSER

ADRB1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADRB1-001
ENSP00000358301
ENST00000369295
P08588 [Direct mapping]
Beta-1 adrenergic receptor
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001659 [temperature homeostasis]
GO:0001996 [positive regulation of heart rate by epinephrine-norepinephrine]
GO:0001997 [positive regulation of the force of heart contraction by epinephrine-norepinephrine]
GO:0002024 [diet induced thermogenesis]
GO:0002025 [vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure]
GO:0004930 [G-protein coupled receptor activity]
GO:0004939 [beta-adrenergic receptor activity]
GO:0004940 [beta1-adrenergic receptor activity]
GO:0005057 [receptor signaling protein activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007189 [adenylate cyclase-activating G-protein coupled receptor signaling pathway]
GO:0007190 [activation of adenylate cyclase activity]
GO:0007267 [cell-cell signaling]
GO:0009409 [response to cold]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030165 [PDZ domain binding]
GO:0030819 [positive regulation of cAMP biosynthetic process]
GO:0031649 [heat generation]
GO:0031694 [alpha-2A adrenergic receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0040015 [negative regulation of multicellular organism growth]
GO:0042596 [fear response]
GO:0043547 [positive regulation of GTPase activity]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0046982 [protein heterodimerization activity]
GO:0050873 [brown fat cell differentiation]
GO:0051379 [epinephrine binding]
GO:0051380 [norepinephrine binding]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
Show all
477 aa
51.2 kDa
Yes 7

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