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CTNNA1

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GENERAL INFORMATION

Gene name

 CTNNA1

Gene description

 Catenin (cadherin-associated protein), alpha 1, 102kDa

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 27
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane & cell junctions.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (validated), Cell Junctions (validated)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA046119 , HPA063535
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane & cell junctions.

Main location

 Plasma membrane (validated), Cell Junctions (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA046119 CACO-2 Plasma membrane
Cell Junctions
HPA046119 SiHa No staining    
HPA046119 U-2 OS No staining    
HPA063535 CACO-2 Plasma membrane
Cell Junctions
HPA063535 SiHa Golgi apparatus
Vesicles
HPA063535 U-2 OS Vesicles
Plasma membrane

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000037815 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA046119 NIH 3T3 No staining

GENE INFORMATION

Gene name

 CTNNA1 (HGNC Symbol)

Synonyms

 CAP102

Description

 Catenin (cadherin-associated protein), alpha 1, 102kDa (HGNC Symbol)

Entrez gene summary

Chromosome

 5

Cytoband

 q31.2

Chromosome location (bp)

 138610967 - 138935034

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000044115 (version 83.38)

Entrez gene

 1495

UniProt

 P35221 (UniProt - Evidence at protein level)

neXtProt

 NX_P35221

Antibodypedia

 CTNNA1 antibodies

PROTEIN BROWSER
«
CTNNA1-001
CTNNA1-006
CTNNA1-007
CTNNA1-008
CTNNA1-010
CTNNA1-011
CTNNA1-014
CTNNA1-015
CTNNA1-016
CTNNA1-017
CTNNA1-023
CTNNA1-024
CTNNA1-025
CTNNA1-026
CTNNA1-027
CTNNA1-028
CTNNA1-029
CTNNA1-030
CTNNA1-031
CTNNA1-034
CTNNA1-035
CTNNA1-036
CTNNA1-037
CTNNA1-038
CTNNA1-040
CTNNA1-201
CTNNA1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTNNA1-001
ENSP00000304669
ENST00000302763
P35221 [Direct mapping]
Catenin alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001541 [ovarian follicle development]
GO:0001669 [acrosomal vesicle]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007406 [negative regulation of neuroblast proliferation]
GO:0007568 [aging]
GO:0008013 [beta-catenin binding]
GO:0008584 [male gonad development]
GO:0014070 [response to organic cyclic compound]
GO:0014704 [intercalated disc]
GO:0015629 [actin cytoskeleton]
GO:0016264 [gap junction assembly]
GO:0016342 [catenin complex]
GO:0016600 [flotillin complex]
GO:0017166 [vinculin binding]
GO:0030027 [lamellipodium]
GO:0031103 [axon regeneration]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0034613 [cellular protein localization]
GO:0042127 [regulation of cell proliferation]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042692 [muscle cell differentiation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043297 [apical junction assembly]
GO:0043627 [response to estrogen]
GO:0044822 [poly(A) RNA binding]
GO:0045216 [cell-cell junction organization]
GO:0045295 [gamma-catenin binding]
GO:0045296 [cadherin binding]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051291 [protein heterooligomerization]
GO:0071681 [cellular response to indole-3-methanol]
GO:2000146 [negative regulation of cell motility]
GO:2001045 [negative regulation of integrin-mediated signaling pathway]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001241 [positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 906 aa
100.1 kDa 		No 0
CTNNA1-006
ENSP00000427821
ENST00000518825
G3XAM7 [Direct mapping]
Catenin (Cadherin-associated protein), alpha 1, 102kDa, isoform CRA_a; Catenin alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0015629 [actin cytoskeleton]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 841 aa
92.7 kDa 		No 0
CTNNA1-007
ENSP00000430304
ENST00000523912
E5RG03 [Direct mapping]
Catenin alpha-1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 156 aa
17.1 kDa 		No 0
CTNNA1-008
ENSP00000428202
ENST00000520339
E5RJL0 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 101 aa
11.2 kDa 		No 0
CTNNA1-010
ENSP00000430078
ENST00000519113
E5RGY6 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 139 aa
15.2 kDa 		No 0
CTNNA1-011
ENSP00000429457
ENST00000520158
E5RIB1 [Direct mapping]
Catenin alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0015629 [actin cytoskeleton]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 215 aa
23.7 kDa 		No 0
CTNNA1-014
ENSP00000430626
ENST00000518910
E5RJ41 [Direct mapping]
Catenin alpha-1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0015629 [actin cytoskeleton]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 161 aa
17.5 kDa 		No 0
CTNNA1-015
ENSP00000428439
ENST00000517980
E5RIE0 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 118 aa
12.9 kDa 		No 0
CTNNA1-016
ENSP00000428049
ENST00000524127
E5RFM3 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 94 aa
10.4 kDa 		No 0
CTNNA1-017
ENSP00000429636
ENST00000522227
E5RHV7 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 123 aa
13.4 kDa 		No 0
CTNNA1-023
ENSP00000430379
ENST00000522013
E5RFK9 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 105 aa
11.6 kDa 		No 0
CTNNA1-024
ENSP00000429569
ENST00000520260
E5RHY5 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 32 aa
3.8 kDa 		No 0
CTNNA1-025
ENSP00000430240
ENST00000523685
E5RGD2 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 128 aa
14.5 kDa 		No 0
CTNNA1-026
ENSP00000430841
ENST00000520865
E5RHR7 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 37 aa
4.3 kDa 		No 0
CTNNA1-027
ENSP00000431118
ENST00000517533
E5RJP7 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 119 aa
13.3 kDa 		No 0
CTNNA1-028
ENSP00000428894
ENST00000519116
E5RFG3 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 92 aa
10.4 kDa 		No 0
CTNNA1-029
ENSP00000430177
ENST00000517656
E5RGG4 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 39 aa
4.5 kDa 		No 0
CTNNA1-030
ENSP00000428044
ENST00000523298
E5RFM5 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 110 aa
12.2 kDa 		No 0
CTNNA1-031
ENSP00000428088
ENST00000519634
E5RGS1 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 50 aa
5.8 kDa 		No 0
CTNNA1-034
ENSP00000430623
ENST00000521640
E5RJ43 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 41 aa
4.7 kDa 		No 0
CTNNA1-035
ENSP00000429103
ENST00000519768
E5RJC9 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 20 aa
2.5 kDa 		No 0
CTNNA1-036
ENSP00000430981
ENST00000521683
E5RGU3 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 71 aa
8.1 kDa 		No 0
CTNNA1-037
ENSP00000428710
ENST00000520522
E5RGS1 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 50 aa
5.8 kDa 		No 0
CTNNA1-038
ENSP00000429738
ENST00000518381
E5RHJ5 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 75 aa
8.6 kDa 		No 0
CTNNA1-040
ENSP00000430076
ENST00000520520
E5RGY7 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 136 aa
14.9 kDa 		No 0
CTNNA1-201
ENSP00000438476
ENST00000540387
P35221 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008013 [beta-catenin binding]
GO:0015629 [actin cytoskeleton]
GO:0016342 [catenin complex]
GO:0017166 [vinculin binding]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042692 [muscle cell differentiation]
GO:0043297 [apical junction assembly]
GO:0044822 [poly(A) RNA binding]
GO:0045216 [cell-cell junction organization]
GO:0045295 [gamma-catenin binding]
GO:0045296 [cadherin binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0071681 [cellular response to indole-3-methanol]
Show all
 536 aa
59.5 kDa 		No 0
CTNNA1-202
ENSP00000486200
ENST00000627109
G3XAM7 [Direct mapping]
Catenin (Cadherin-associated protein), alpha 1, 102kDa, isoform CRA_a; Catenin alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0015629 [actin cytoskeleton]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 841 aa
92.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.