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CTNNA1

GENERAL INFORMATION

Gene name

 CTNNA1

Gene description

 Catenin (cadherin-associated protein), alpha 1, 102kDa

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 27
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression at variable levels in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA046119 , CAB021089
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CTNNA1 (HGNC Symbol)

Synonyms

 CAP102

Description

 Catenin (cadherin-associated protein), alpha 1, 102kDa (HGNC Symbol)

Entrez gene summary

Chromosome

 5

Cytoband

 q31.2

Chromosome location (bp)

 138610967 - 138935034

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000044115 (version 83.38)

Entrez gene

 1495

UniProt

 P35221 (UniProt - Evidence at protein level)

neXtProt

 NX_P35221

Antibodypedia

 CTNNA1 antibodies

PROTEIN BROWSER
«
CTNNA1-001
CTNNA1-006
CTNNA1-007
CTNNA1-008
CTNNA1-010
CTNNA1-011
CTNNA1-014
CTNNA1-015
CTNNA1-016
CTNNA1-017
CTNNA1-023
CTNNA1-024
CTNNA1-025
CTNNA1-026
CTNNA1-027
CTNNA1-028
CTNNA1-029
CTNNA1-030
CTNNA1-031
CTNNA1-034
CTNNA1-035
CTNNA1-036
CTNNA1-037
CTNNA1-038
CTNNA1-040
CTNNA1-201
CTNNA1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTNNA1-001
ENSP00000304669
ENST00000302763
P35221 [Direct mapping]
Catenin alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001541 [ovarian follicle development]
GO:0001669 [acrosomal vesicle]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005912 [adherens junction]
GO:0005913 [cell-cell adherens junction]
GO:0005915 [zonula adherens]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007406 [negative regulation of neuroblast proliferation]
GO:0007568 [aging]
GO:0008013 [beta-catenin binding]
GO:0008584 [male gonad development]
GO:0014070 [response to organic cyclic compound]
GO:0014704 [intercalated disc]
GO:0015629 [actin cytoskeleton]
GO:0016264 [gap junction assembly]
GO:0016342 [catenin complex]
GO:0016600 [flotillin complex]
GO:0017166 [vinculin binding]
GO:0030027 [lamellipodium]
GO:0031103 [axon regeneration]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0034613 [cellular protein localization]
GO:0042127 [regulation of cell proliferation]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042692 [muscle cell differentiation]
GO:0043066 [negative regulation of apoptotic process]
GO:0043297 [apical junction assembly]
GO:0043627 [response to estrogen]
GO:0044822 [poly(A) RNA binding]
GO:0045216 [cell-cell junction organization]
GO:0045295 [gamma-catenin binding]
GO:0045296 [cadherin binding]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051291 [protein heterooligomerization]
GO:0071681 [cellular response to indole-3-methanol]
GO:2000146 [negative regulation of cell motility]
GO:2001045 [negative regulation of integrin-mediated signaling pathway]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
GO:2001241 [positive regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 906 aa
100.1 kDa 		No 0
CTNNA1-006
ENSP00000427821
ENST00000518825
G3XAM7 [Direct mapping]
Catenin (Cadherin-associated protein), alpha 1, 102kDa, isoform CRA_a; Catenin alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0015629 [actin cytoskeleton]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 841 aa
92.7 kDa 		No 0
CTNNA1-007
ENSP00000430304
ENST00000523912
E5RG03 [Direct mapping]
Catenin alpha-1
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 156 aa
17.1 kDa 		No 0
CTNNA1-008
ENSP00000428202
ENST00000520339
E5RJL0 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 101 aa
11.2 kDa 		No 0
CTNNA1-010
ENSP00000430078
ENST00000519113
E5RGY6 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 139 aa
15.2 kDa 		No 0
CTNNA1-011
ENSP00000429457
ENST00000520158
E5RIB1 [Direct mapping]
Catenin alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0015629 [actin cytoskeleton]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 215 aa
23.7 kDa 		No 0
CTNNA1-014
ENSP00000430626
ENST00000518910
E5RJ41 [Direct mapping]
Catenin alpha-1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0015629 [actin cytoskeleton]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 161 aa
17.5 kDa 		No 0
CTNNA1-015
ENSP00000428439
ENST00000517980
E5RIE0 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 118 aa
12.9 kDa 		No 0
CTNNA1-016
ENSP00000428049
ENST00000524127
E5RFM3 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 94 aa
10.4 kDa 		No 0
CTNNA1-017
ENSP00000429636
ENST00000522227
E5RHV7 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 123 aa
13.4 kDa 		No 0
CTNNA1-023
ENSP00000430379
ENST00000522013
E5RFK9 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 105 aa
11.6 kDa 		No 0
CTNNA1-024
ENSP00000429569
ENST00000520260
E5RHY5 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 32 aa
3.8 kDa 		No 0
CTNNA1-025
ENSP00000430240
ENST00000523685
E5RGD2 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 128 aa
14.5 kDa 		No 0
CTNNA1-026
ENSP00000430841
ENST00000520865
E5RHR7 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 37 aa
4.3 kDa 		No 0
CTNNA1-027
ENSP00000431118
ENST00000517533
E5RJP7 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 119 aa
13.3 kDa 		No 0
CTNNA1-028
ENSP00000428894
ENST00000519116
E5RFG3 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 92 aa
10.4 kDa 		No 0
CTNNA1-029
ENSP00000430177
ENST00000517656
E5RGG4 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 39 aa
4.5 kDa 		No 0
CTNNA1-030
ENSP00000428044
ENST00000523298
E5RFM5 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 110 aa
12.2 kDa 		No 0
CTNNA1-031
ENSP00000428088
ENST00000519634
E5RGS1 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 50 aa
5.8 kDa 		No 0
CTNNA1-034
ENSP00000430623
ENST00000521640
E5RJ43 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 41 aa
4.7 kDa 		No 0
CTNNA1-035
ENSP00000429103
ENST00000519768
E5RJC9 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 20 aa
2.5 kDa 		No 0
CTNNA1-036
ENSP00000430981
ENST00000521683
E5RGU3 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 71 aa
8.1 kDa 		No 0
CTNNA1-037
ENSP00000428710
ENST00000520522
E5RGS1 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 50 aa
5.8 kDa 		No 0
CTNNA1-038
ENSP00000429738
ENST00000518381
E5RHJ5 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 75 aa
8.6 kDa 		No 0
CTNNA1-040
ENSP00000430076
ENST00000520520
E5RGY7 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 136 aa
14.9 kDa 		No 0
CTNNA1-201
ENSP00000438476
ENST00000540387
P35221 [Direct mapping]
Catenin alpha-1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008013 [beta-catenin binding]
GO:0015629 [actin cytoskeleton]
GO:0016342 [catenin complex]
GO:0017166 [vinculin binding]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0042692 [muscle cell differentiation]
GO:0043297 [apical junction assembly]
GO:0044822 [poly(A) RNA binding]
GO:0045216 [cell-cell junction organization]
GO:0045295 [gamma-catenin binding]
GO:0045296 [cadherin binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0051015 [actin filament binding]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0071681 [cellular response to indole-3-methanol]
Show all
 536 aa
59.5 kDa 		No 0
CTNNA1-202
ENSP00000486200
ENST00000627109
G3XAM7 [Direct mapping]
Catenin (Cadherin-associated protein), alpha 1, 102kDa, isoform CRA_a; Catenin alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005829 [cytosol]
GO:0005912 [adherens junction]
GO:0007015 [actin filament organization]
GO:0007155 [cell adhesion]
GO:0008013 [beta-catenin binding]
GO:0015629 [actin cytoskeleton]
GO:0045296 [cadherin binding]
GO:0051015 [actin filament binding]
GO:0090136 [epithelial cell-cell adhesion]
Show all
 841 aa
92.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.