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EPHA3

GENERAL INFORMATION

Gene name

 EPHA3

Gene description

 EPH receptor A3

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (AF22)
HPA (normal tissue):Tissue enhanced (prostate)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB010462
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB010462

GENE INFORMATION

Gene name

 EPHA3 (HGNC Symbol)

Synonyms

 ETK, ETK1, HEK, HEK4, TYRO4

Description

 EPH receptor A3 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p11.1

Chromosome location (bp)

 89107524 - 89482134

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000044524 (version 83.38)

Entrez gene

 2042

UniProt

 P29320 (UniProt - Evidence at protein level)

neXtProt

 NX_P29320

Antibodypedia

 EPHA3 antibodies

PROTEIN BROWSER
EPHA3-001
EPHA3-002
EPHA3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EPHA3-001
ENSP00000337451
ENST00000336596
P29320 [Direct mapping]
Ephrin type-A receptor 3
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0010976 [positive regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0043087 [regulation of GTPase activity]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051893 [regulation of focal adhesion assembly]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071300 [cellular response to retinoic acid]
GO:0097155 [fasciculation of sensory neuron axon]
GO:0097156 [fasciculation of motor neuron axon]
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 983 aa
110.1 kDa 		Yes 2
EPHA3-002
ENSP00000419190
ENST00000494014
C9JXA2 [Direct mapping]
Receptor protein-tyrosine kinase
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0048013 [ephrin receptor signaling pathway]
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 918 aa
103.1 kDa 		Yes 2
EPHA3-003
ENSP00000399926
ENST00000452448
P29320 [Direct mapping]
Ephrin type-A receptor 3
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005003 [ephrin receptor activity]
GO:0005004 [GPI-linked ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005576 [extracellular region]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0010717 [regulation of epithelial to mesenchymal transition]
GO:0010976 [positive regulation of neuron projection development]
GO:0016021 [integral component of membrane]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0043087 [regulation of GTPase activity]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051893 [regulation of focal adhesion assembly]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071300 [cellular response to retinoic acid]
GO:0097155 [fasciculation of sensory neuron axon]
GO:0097156 [fasciculation of motor neuron axon]
Show all
 539 aa
60.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.