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Moderate cytoplasmic immunoreactivity was observed in malignant cells. Thyroid carcinomas as well as a few cases of gastric and liver cancer were strongly strained.
GENE INFORMATION
Gene name
HSPA5 (HGNC Symbol)
Synonyms
BiP, GRP78
Description
Heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]