Expression of GPM6B in cancer - Summary - The Human Protein Atlas

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GPM6B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GPM6B
Gene description	Glycoprotein M6B
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, melanoma)
HPA (cell line):	Cell line enhanced (AF22, AN3-CA, SK-MEL-30)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High expression in processes in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA002913
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable).
Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA002913

GENE INFORMATION
Gene name	GPM6B (HGNC Symbol)
Synonyms	M6B, MGC17150, MGC54284
Description	Glycoprotein M6B (HGNC Symbol)
Entrez gene summary	This gene encodes a membrane glycoprotein that belongs to the proteolipid protein family. Proteolipid protein family members are expressed in most brain regions and are thought to be involved in cellular housekeeping functions, such as membrane trafficking and cell-to-cell communication. [provided by RefSeq, Apr 2009]
Chromosome	X
Cytoband	p22.2
Chromosome location (bp)	13771031 - 13938638
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000046653 (version 83.38)
Entrez gene	2824
UniProt	Q13491 (UniProt - Evidence at protein level)
neXtProt	NX_Q13491
Antibodypedia	GPM6B antibodies

PROTEIN BROWSER

GPM6B-001	GPM6B-002	GPM6B-003	GPM6B-004	GPM6B-005	GPM6B-007	GPM6B-008	GPM6B-011	GPM6B-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPM6B-001 ENSP00000389915 ENST00000454189	Q13491 [Direct mapping] Neuronal membrane glycoprotein M6-b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0003674 [molecular_function] GO:0005886 [plasma membrane] GO:0007399 [nervous system development] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0032956 [regulation of actin cytoskeleton organization] GO:0045121 [membrane raft] GO:0051612 [negative regulation of serotonin uptake] GO:0051893 [regulation of focal adhesion assembly] GO:0085029 [extracellular matrix assembly] GO:2000009 [negative regulation of protein localization to cell surface] Show all	246 aa 26.8 kDa	No	4
GPM6B-002 ENSP00000349420 ENST00000356942	Q13491 [Direct mapping] Neuronal membrane glycoprotein M6-b A0A024RBV7 [Target identity:100%; Query identity:100%] Glycoprotein M6B, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0003674 [molecular_function] GO:0005886 [plasma membrane] GO:0007399 [nervous system development] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0032956 [regulation of actin cytoskeleton organization] GO:0045121 [membrane raft] GO:0051612 [negative regulation of serotonin uptake] GO:0051893 [regulation of focal adhesion assembly] GO:0085029 [extracellular matrix assembly] GO:2000009 [negative regulation of protein localization to cell surface] Show all	265 aa 29 kDa	No	4
GPM6B-003 ENSP00000316861 ENST00000316715	Q13491 [Direct mapping] Neuronal membrane glycoprotein M6-b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0003674 [molecular_function] GO:0005886 [plasma membrane] GO:0007399 [nervous system development] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0032956 [regulation of actin cytoskeleton organization] GO:0045121 [membrane raft] GO:0051612 [negative regulation of serotonin uptake] GO:0051893 [regulation of focal adhesion assembly] GO:0085029 [extracellular matrix assembly] GO:2000009 [negative regulation of protein localization to cell surface] Show all	328 aa 36.2 kDa	No	4
GPM6B-004 ENSP00000418594 ENST00000475307	C9J028 [Direct mapping] Neuronal membrane glycoprotein M6-b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	107 aa 11.5 kDa	No	2
GPM6B-005 ENSP00000381402 ENST00000398361	B7Z248 [Direct mapping] Neuronal membrane glycoprotein M6-b; cDNA FLJ59871, highly similar to Neuronal membrane glycoprotein M6-b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	179 aa 19.9 kDa	No	3
GPM6B-007 ENSP00000419904 ENST00000493677	B7Z613 [Direct mapping] Neuronal membrane glycoprotein M6-b; cDNA FLJ54144, highly similar to Neuronal membrane glycoprotein M6-b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	302 aa 33.3 kDa	No	4
GPM6B-008 ENSP00000347258 ENST00000355135	Q13491 [Direct mapping] Neuronal membrane glycoprotein M6-b A0A024RBX1 [Target identity:100%; Query identity:100%] Glycoprotein M6B, isoform CRA_d Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001503 [ossification] GO:0003674 [molecular_function] GO:0005886 [plasma membrane] GO:0007399 [nervous system development] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0030154 [cell differentiation] GO:0030501 [positive regulation of bone mineralization] GO:0032956 [regulation of actin cytoskeleton organization] GO:0045121 [membrane raft] GO:0051612 [negative regulation of serotonin uptake] GO:0051893 [regulation of focal adhesion assembly] GO:0085029 [extracellular matrix assembly] GO:2000009 [negative regulation of protein localization to cell surface] Show all	305 aa 33.5 kDa	No	4
GPM6B-011 ENSP00000419779 ENST00000468080	C9JZE8 [Direct mapping] Neuronal membrane glycoprotein M6-b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	76 aa 8.5 kDa	No	2
GPM6B-012 ENSP00000418199 ENST00000493085	C9J8H8 [Direct mapping] Neuronal membrane glycoprotein M6-b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	95 aa 10.5 kDa	No	2

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