Expression of CTPS2 in cancer - Summary - The Human Protein Atlas

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CTPS2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CTPS2
Gene description	CTP synthase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA017437
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and urothelial cancer (favourable).
Liver cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017437

GENE INFORMATION
Gene name	CTPS2
Synonyms
Description	CTP synthase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	p22.2
Chromosome location (bp)	16588003 - 16712936
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000047230 (version 83.38)
Entrez gene	56474
UniProt	Q9NRF8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRF8
Antibodypedia	CTPS2 antibodies

PROTEIN BROWSER

CTPS2-001	CTPS2-002	CTPS2-004	CTPS2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTPS2-001 ENSP00000369590 ENST00000380241	Q9NRF8 [Direct mapping] CTP synthase 2 A0A024RC00 [Target identity:100%; Query identity:100%] CTP synthase Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003883 [CTP synthase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006220 [pyrimidine nucleotide metabolic process] GO:0006221 [pyrimidine nucleotide biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0044210 ['de novo' CTP biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	586 aa 65.7 kDa	No	0
CTPS2-002 ENSP00000352222 ENST00000359276	Q9NRF8 [Direct mapping] CTP synthase 2 A0A024RC00 [Target identity:100%; Query identity:100%] CTP synthase Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003883 [CTP synthase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006220 [pyrimidine nucleotide metabolic process] GO:0006221 [pyrimidine nucleotide biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0044210 ['de novo' CTP biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	586 aa 65.7 kDa	No	0
CTPS2-004 ENSP00000400431 ENST00000455276	H0Y5S6 [Direct mapping] CTP synthase 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003883 [CTP synthase activity] GO:0006221 [pyrimidine nucleotide biosynthetic process] Show all	132 aa 14.5 kDa	No	0
CTPS2-201 ENSP00000401264 ENST00000443824	Q9NRF8 [Direct mapping] CTP synthase 2 A0A024RC00 [Target identity:100%; Query identity:100%] CTP synthase Show all	Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003883 [CTP synthase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006220 [pyrimidine nucleotide metabolic process] GO:0006221 [pyrimidine nucleotide biosynthetic process] GO:0006541 [glutamine metabolic process] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0044210 ['de novo' CTP biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	586 aa 65.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.