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POLR2B

GENERAL INFORMATION

Gene name

 POLR2B

Gene description

 Polymerase (RNA) II (DNA directed) polypeptide B, 140kDa

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
RNA polymerase related proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA037506
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037506

GENE INFORMATION

Gene name

 POLR2B (HGNC Symbol)

Synonyms

 RPB2

Description

 Polymerase (RNA) II (DNA directed) polypeptide B, 140kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes the second largest subunit of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase that catalyzes the transcription of DNA into precursors of mRNA, snRNA and microRNA. This subunit and the largest subunit form opposite sides of the center cleft of Pol II. Deletion of the flap loop region of this subunit results in a decrease in the rate of transcriptional elongation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Chromosome

 4

Cytoband

 q12

Chromosome location (bp)

 56977722 - 57031168

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000047315 (version 83.38)

Entrez gene

 5431

UniProt

 P30876 (UniProt - Evidence at protein level)

neXtProt

 NX_P30876

Antibodypedia

 POLR2B antibodies

PROTEIN BROWSER
POLR2B-001
POLR2B-003
POLR2B-005
POLR2B-006
POLR2B-014
POLR2B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLR2B-001
ENSP00000370625
ENST00000381227
P30876 [Direct mapping]
DNA-directed RNA polymerase II subunit RPB2
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001055 [RNA polymerase II activity]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0032549 [ribonucleoside binding]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0050434 [positive regulation of viral transcription]
Show all
 1174 aa
133.9 kDa 		No 0
POLR2B-003
ENSP00000408638
ENST00000450656
C9JMN3 [Direct mapping]
DNA-directed RNA polymerase II subunit RPB2
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001055 [RNA polymerase II activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0032549 [ribonucleoside binding]
Show all
 64 aa
7.6 kDa 		No 0
POLR2B-005
ENSP00000407728
ENST00000433463
C9JZW8 [Direct mapping]
DNA-directed RNA polymerase II subunit RPB2
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001055 [RNA polymerase II activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0032549 [ribonucleoside binding]
Show all
 76 aa
8.8 kDa 		No 0
POLR2B-006
ENSP00000391452
ENST00000441246
C9J2Y9 [Direct mapping]
DNA-directed RNA polymerase
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001055 [RNA polymerase II activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0032549 [ribonucleoside binding]
Show all
 1167 aa
133.1 kDa 		No 0
POLR2B-014
ENSP00000391096
ENST00000431623
C9J4M6 [Direct mapping]
DNA-directed RNA polymerase
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Predicted intracellular proteins
RNA polymerase related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001055 [RNA polymerase II activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0032549 [ribonucleoside binding]
Show all
 1099 aa
125.2 kDa 		No 0
POLR2B-201
ENSP00000312735
ENST00000314595
P30876 [Direct mapping]
DNA-directed RNA polymerase II subunit RPB2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
RNA polymerase related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0001055 [RNA polymerase II activity]
GO:0003677 [DNA binding]
GO:0003899 [DNA-directed RNA polymerase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005665 [DNA-directed RNA polymerase II, core complex]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0031047 [gene silencing by RNA]
GO:0032549 [ribonucleoside binding]
GO:0034587 [piRNA metabolic process]
GO:0035019 [somatic stem cell population maintenance]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0050434 [positive regulation of viral transcription]
Show all
 1174 aa
133.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.