Tissue expression of CP - Summary - The Human Protein Atlas

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CP

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CP
Gene description	Ceruloplasmin (ferroxidase)
Protein class	Cancer-related genes Candidate cardiovascular disease genes Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (liver)
GTEx:	Tissue enriched (liver)
FANTOM5:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Distinct positivity in plasma and extracellular matrix with low cytoplasmic expression in several tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 2 antibodies. HPA001834 , CAB008591
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)

GENE INFORMATION
Gene name	CP
Synonyms
Description	Ceruloplasmin (ferroxidase) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]
Chromosome	3
Cytoband
Chromosome location (bp)	149162410 - 149222055
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000047457 (version 83.38)
Entrez gene	1356
UniProt	P00450 (UniProt - Evidence at protein level)
neXtProt	NX_P00450
Antibodypedia	CP antibodies

PROTEIN BROWSER

CP-001	CP-003	CP-006	CP-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CP-001 ENSP00000264613 ENST00000264613	P00450 [Direct mapping] Ceruloplasmin Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Candidate cardiovascular disease genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0004322 [ferroxidase activity] GO:0005507 [copper ion binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0006825 [copper ion transport] GO:0006879 [cellular iron ion homeostasis] GO:0007568 [aging] GO:0007584 [response to nutrient] GO:0016491 [oxidoreductase activity] GO:0030324 [lung development] GO:0046658 [anchored component of plasma membrane] GO:0046688 [response to copper ion] GO:0051087 [chaperone binding] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	1065 aa 122.2 kDa	Yes	0
CP-003 ENSP00000426888 ENST00000455472	D6RE86 [Direct mapping] Ceruloplasmin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005507 [copper ion binding] Show all	179 aa 20.9 kDa	Yes	0
CP-006 ENSP00000420367 ENST00000479771	H7C5N5 [Direct mapping] Ceruloplasmin Show all	Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005507 [copper ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	225 aa 26.1 kDa	No	0
CP-012 ENSP00000420545 ENST00000494544	H7C5R1 [Direct mapping] Ceruloplasmin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005507 [copper ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	852 aa 97.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.