Expression of WWC3 in cancer - Summary - The Human Protein Atlas

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WWC3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	WWC3
Gene description	WWC family member 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (T-47d)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA039814
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039814

GENE INFORMATION
Gene name	WWC3 (HGNC Symbol)
Synonyms	BM042, KIAA1280
Description	WWC family member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]
Chromosome	X
Cytoband	p22.2
Chromosome location (bp)	10015562 - 10144478
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000047644 (version 83.38)
Entrez gene	55841
UniProt	Q9ULE0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9ULE0
Antibodypedia	WWC3 antibodies

PROTEIN BROWSER

WWC3-001	WWC3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WWC3-001 ENSP00000370242 ENST00000380861	Q9ULE0 [Direct mapping] Protein WWC3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0019900 [kinase binding] GO:0032947 [protein complex scaffold] GO:0035331 [negative regulation of hippo signaling] GO:0046621 [negative regulation of organ growth] Show all	1092 aa 122.7 kDa	No	0
WWC3-201 ENSP00000399584 ENST00000454666	A0A0A0MSQ8 [Direct mapping] Protein WWC3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1216 aa 136.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.