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HDAC9

GENERAL INFORMATION

Gene name

 HDAC9

Gene description

 Histone deacetylase 9

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 16
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (SH-SY5Y, WM-115)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly general nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA028926
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA028926

GENE INFORMATION

Gene name

 HDAC9 (HGNC Symbol)

Synonyms

 HD7, HDAC, HDAC7B, KIAA0744, MITR

Description

 Histone deacetylase 9 (HGNC Symbol)

Entrez gene summary

 Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 p21.1

Chromosome location (bp)

 18086949 - 19002416

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000048052 (version 83.38)

Entrez gene

 9734

UniProt

 Q9UKV0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKV0

Antibodypedia

 HDAC9 antibodies

PROTEIN BROWSER
«
HDAC9-001
HDAC9-002
HDAC9-004
HDAC9-005
HDAC9-006
HDAC9-008
HDAC9-010
HDAC9-011
HDAC9-013
HDAC9-015
HDAC9-017
HDAC9-021
HDAC9-022
HDAC9-023
HDAC9-025
HDAC9-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HDAC9-001
ENSP00000384657
ENST00000406451
Q9UKV0 [Direct mapping]
Histone deacetylase 9
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0007219 [Notch signaling pathway]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0016568 [chromatin modification]
GO:0016575 [histone deacetylation]
GO:0030183 [B cell differentiation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032869 [cellular response to insulin stimulus]
GO:0033558 [protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035097 [histone methyltransferase complex]
GO:0042113 [B cell activation]
GO:0042826 [histone deacetylase binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048742 [regulation of skeletal muscle fiber development]
GO:0051153 [regulation of striated muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
Show all
 1066 aa
117.2 kDa 		No 0
HDAC9-002
ENSP00000384382
ENST00000405010
Q9UKV0 [Direct mapping]
Histone deacetylase 9
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0007219 [Notch signaling pathway]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0016575 [histone deacetylation]
GO:0030183 [B cell differentiation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032869 [cellular response to insulin stimulus]
GO:0033558 [protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035097 [histone methyltransferase complex]
GO:0042113 [B cell activation]
GO:0042826 [histone deacetylase binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048742 [regulation of skeletal muscle fiber development]
GO:0051153 [regulation of striated muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
Show all
 590 aa
65.9 kDa 		No 0
HDAC9-004
ENSP00000384017
ENST00000406072
B5MCF1 [Direct mapping]
Histone deacetylase 9
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Predicted intracellular proteins
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 577 aa
64.2 kDa 		No 0
HDAC9-005
ENSP00000401669
ENST00000417496
Q9UKV0 [Direct mapping]
Histone deacetylase 9
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0007219 [Notch signaling pathway]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0016575 [histone deacetylation]
GO:0030183 [B cell differentiation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032869 [cellular response to insulin stimulus]
GO:0033558 [protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035097 [histone methyltransferase complex]
GO:0042113 [B cell activation]
GO:0042826 [histone deacetylase binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048742 [regulation of skeletal muscle fiber development]
GO:0051153 [regulation of striated muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
Show all
 588 aa
65.5 kDa 		No 0
HDAC9-006
ENSP00000409003
ENST00000433709
C9JLX1 [Direct mapping]
Histone deacetylase 9
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Predicted intracellular proteins
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 23 aa
2.4 kDa 		No 0
HDAC9-008
ENSP00000412497
ENST00000413509
C9IZS0 [Direct mapping]
Histone deacetylase 9
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Predicted intracellular proteins
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 138 aa
16.5 kDa 		No 0
HDAC9-010
ENSP00000411422
ENST00000430454
C9J835 [Direct mapping]
Histone deacetylase 9
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Predicted intracellular proteins
Show all
 71 aa
8.6 kDa 		No 0
HDAC9-011
ENSP00000392564
ENST00000413380
C9J1W4 [Direct mapping]
Histone deacetylase 9
Show all
Predicted intracellular proteins
Show all
 148 aa
17.6 kDa 		No 0
HDAC9-013
ENSP00000404763
ENST00000441986
C9JD56 [Direct mapping]
Histone deacetylase 9
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Predicted intracellular proteins
Show all
 110 aa
13.3 kDa 		No 0
HDAC9-015
ENSP00000388568
ENST00000456174
Q9UKV0 [Direct mapping]
Histone deacetylase 9
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0007219 [Notch signaling pathway]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0016575 [histone deacetylation]
GO:0030183 [B cell differentiation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032869 [cellular response to insulin stimulus]
GO:0033558 [protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035097 [histone methyltransferase complex]
GO:0042113 [B cell activation]
GO:0042826 [histone deacetylase binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048742 [regulation of skeletal muscle fiber development]
GO:0051153 [regulation of striated muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
Show all
 562 aa
62.9 kDa 		No 0
HDAC9-017
ENSP00000383912
ENST00000401921
Q9UKV0 [Direct mapping]
Histone deacetylase 9
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0007219 [Notch signaling pathway]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0016568 [chromatin modification]
GO:0016575 [histone deacetylation]
GO:0030183 [B cell differentiation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032869 [cellular response to insulin stimulus]
GO:0033558 [protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035097 [histone methyltransferase complex]
GO:0042113 [B cell activation]
GO:0042826 [histone deacetylase binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048742 [regulation of skeletal muscle fiber development]
GO:0051153 [regulation of striated muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
Show all
 1025 aa
112.5 kDa 		No 0
HDAC9-021
ENSP00000408617
ENST00000441542
Q9UKV0 [Direct mapping]
Histone deacetylase 9
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001975 [response to amphetamine]
GO:0003714 [transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0007219 [Notch signaling pathway]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0016568 [chromatin modification]
GO:0016575 [histone deacetylation]
GO:0030182 [neuron differentiation]
GO:0030183 [B cell differentiation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032869 [cellular response to insulin stimulus]
GO:0033558 [protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035097 [histone methyltransferase complex]
GO:0042113 [B cell activation]
GO:0042826 [histone deacetylase binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048742 [regulation of skeletal muscle fiber development]
GO:0051153 [regulation of striated muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
Show all
 1069 aa
117.6 kDa 		No 0
HDAC9-022
ENSP00000430036
ENST00000524023
Q9UKV0 [Direct mapping]
Histone deacetylase 9
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0007219 [Notch signaling pathway]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0016575 [histone deacetylation]
GO:0030183 [B cell differentiation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032869 [cellular response to insulin stimulus]
GO:0033558 [protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035097 [histone methyltransferase complex]
GO:0042113 [B cell activation]
GO:0042826 [histone deacetylase binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048742 [regulation of skeletal muscle fiber development]
GO:0051153 [regulation of striated muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
Show all
 513 aa
57.1 kDa 		No 0
HDAC9-023
ENSP00000410337
ENST00000432645
Q9UKV0 [Direct mapping]
Histone deacetylase 9
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0007219 [Notch signaling pathway]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0016568 [chromatin modification]
GO:0016575 [histone deacetylation]
GO:0030183 [B cell differentiation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032869 [cellular response to insulin stimulus]
GO:0033558 [protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035097 [histone methyltransferase complex]
GO:0042113 [B cell activation]
GO:0042826 [histone deacetylase binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048742 [regulation of skeletal muscle fiber development]
GO:0051153 [regulation of striated muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
Show all
 1011 aa
111.3 kDa 		No 0
HDAC9-025
ENSP00000395655
ENST00000428307
Q9UKV0 [Direct mapping]
Histone deacetylase 9
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000118 [histone deacetylase complex]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003714 [transcription corepressor activity]
GO:0004407 [histone deacetylase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006954 [inflammatory response]
GO:0007219 [Notch signaling pathway]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0016575 [histone deacetylation]
GO:0030183 [B cell differentiation]
GO:0032041 [NAD-dependent histone deacetylase activity (H3-K14 specific)]
GO:0032869 [cellular response to insulin stimulus]
GO:0033558 [protein deacetylase activity]
GO:0034983 [peptidyl-lysine deacetylation]
GO:0035097 [histone methyltransferase complex]
GO:0042113 [B cell activation]
GO:0042826 [histone deacetylase binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
GO:0048742 [regulation of skeletal muscle fiber development]
GO:0051153 [regulation of striated muscle cell differentiation]
GO:0070491 [repressing transcription factor binding]
GO:0070932 [histone H3 deacetylation]
GO:0070933 [histone H4 deacetylation]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
Show all
 546 aa
60.8 kDa 		No 0
HDAC9-201
ENSP00000478829
ENST00000622668
B7Z3P7 [Direct mapping]
Histone deacetylase 9; cDNA FLJ53343, highly similar to Histone deacetylase 9; cDNA, FLJ79008, highly similar to Histone deacetylase 9
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
 549 aa
61.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.