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RRM2B

GENERAL INFORMATION

Gene name

 RRM2B

Gene description

 Ribonucleotide reductase M2 B (TP53 inducible)

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA028812 , CAB006854
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028812
CAB006854

GENE INFORMATION

Gene name

 RRM2B (HGNC Symbol)

Synonyms

 p53R2

Description

 Ribonucleotide reductase M2 B (TP53 inducible) (HGNC Symbol)

Entrez gene summary

 This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]

Chromosome

 8

Cytoband

 q22.3

Chromosome location (bp)

 102204502 - 102239118

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000048392 (version 83.38)

Entrez gene

 50484

UniProt

 Q7LG56 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7LG56

Antibodypedia

 RRM2B antibodies

PROTEIN BROWSER
RRM2B-001
RRM2B-002
RRM2B-003
RRM2B-004
RRM2B-005
RRM2B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RRM2B-001
ENSP00000251810
ENST00000251810
Q7LG56 [Direct mapping]
Ribonucleoside-diphosphate reductase subunit M2 B
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001822 [kidney development]
GO:0003014 [renal system process]
GO:0004748 [ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005971 [ribonucleoside-diphosphate reductase complex]
GO:0006264 [mitochondrial DNA replication]
GO:0006281 [DNA repair]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006979 [response to oxidative stress]
GO:0009186 [deoxyribonucleoside diphosphate metabolic process]
GO:0009200 [deoxyribonucleoside triphosphate metabolic process]
GO:0009263 [deoxyribonucleotide biosynthetic process]
GO:0010467 [gene expression]
GO:0014075 [response to amine]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:1902254 [negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
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 351 aa
40.7 kDa 		No 1
RRM2B-002
ENSP00000429140
ENST00000519962
Q7LG56 [Direct mapping]
Ribonucleoside-diphosphate reductase subunit M2 B
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004748 [ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005971 [ribonucleoside-diphosphate reductase complex]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0009186 [deoxyribonucleoside diphosphate metabolic process]
GO:0009263 [deoxyribonucleotide biosynthetic process]
GO:0010467 [gene expression]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 66 aa
7.6 kDa 		No 0
RRM2B-003
ENSP00000428115
ENST00000522368
H0YAV1 [Direct mapping]
Ribonucleoside-diphosphate reductase subunit M2 B
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0009186 [deoxyribonucleoside diphosphate metabolic process]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 408 aa
47 kDa 		No 1
RRM2B-004
ENSP00000430641
ENST00000519317
Q7LG56 [Direct mapping]
Ribonucleoside-diphosphate reductase subunit M2 B
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004748 [ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005971 [ribonucleoside-diphosphate reductase complex]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0009186 [deoxyribonucleoside diphosphate metabolic process]
GO:0009263 [deoxyribonucleotide biosynthetic process]
GO:0010467 [gene expression]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 139 aa
16 kDa 		No 0
RRM2B-005
ENSP00000379248
ENST00000395912
Q7LG56 [Direct mapping]
Ribonucleoside-diphosphate reductase subunit M2 B
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004748 [ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005971 [ribonucleoside-diphosphate reductase complex]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0009186 [deoxyribonucleoside diphosphate metabolic process]
GO:0009263 [deoxyribonucleotide biosynthetic process]
GO:0010467 [gene expression]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 299 aa
34.5 kDa 		No 1
RRM2B-201
ENSP00000484318
ENST00000621845
A0A0C4DGZ6 [Direct mapping]
Ribonucleoside-diphosphate reductase subunit M2 B
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0009186 [deoxyribonucleoside diphosphate metabolic process]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 297 aa
34.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.