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LMO3

GENERAL INFORMATION

Gene name

 LMO3

Gene description

 LIM domain only 3 (rhombotin-like 2)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 21
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (thyroid cancer)
HPA (cell line):Group enriched (LHCN-M2, NTERA-2, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 LMO3 (HGNC Symbol)

Synonyms

 DAT1, RBTNL2, Rhom-3

Description

 LIM domain only 3 (rhombotin-like 2) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 12

Cytoband

 p12.3

Chromosome location (bp)

 16548373 - 16610594

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000048540 (version 83.38)

Entrez gene

 55885

UniProt

 Q8TAP4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TAP4

Antibodypedia

 LMO3 antibodies

PROTEIN BROWSER
«
LMO3-001
LMO3-003
LMO3-007
LMO3-010
LMO3-011
LMO3-013
LMO3-014
LMO3-016
LMO3-019
LMO3-020
LMO3-021
LMO3-022
LMO3-024
LMO3-025
LMO3-029
LMO3-030
LMO3-031
LMO3-201
LMO3-202
LMO3-203
LMO3-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LMO3-001
ENSP00000445751
ENST00000540848
Q8TAP4 [Direct mapping]
LIM domain only protein 3
A0A024RAT1 [Target identity:100%; Query identity:100%]
LIM domain only 3 (Rhombotin-like 2), isoform CRA_b
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:2000324 [positive regulation of glucocorticoid receptor signaling pathway]
Show all
 145 aa
16.6 kDa 		No 0
LMO3-003
ENSP00000412479
ENST00000441439
Q8TAP4 [Direct mapping]
LIM domain only protein 3
A0A024RAT1 [Target identity:100%; Query identity:100%]
LIM domain only 3 (Rhombotin-like 2), isoform CRA_b
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:2000324 [positive regulation of glucocorticoid receptor signaling pathway]
Show all
 145 aa
16.6 kDa 		No 0
LMO3-007
ENSP00000442786
ENST00000540445
Q8TAP4 [Direct mapping]
LIM domain only protein 3
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   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:2000324 [positive regulation of glucocorticoid receptor signaling pathway]
Show all
 167 aa
19.1 kDa 		No 0
LMO3-010
ENSP00000413703
ENST00000447609
Q8TAP4 [Direct mapping]
LIM domain only protein 3
A0A024RAT1 [Target identity:100%; Query identity:100%]
LIM domain only 3 (Rhombotin-like 2), isoform CRA_b
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:2000324 [positive regulation of glucocorticoid receptor signaling pathway]
Show all
 145 aa
16.6 kDa 		No 0
LMO3-011
ENSP00000440099
ENST00000537304
Q8TAP4 [Direct mapping]
LIM domain only protein 3
A0A024RAT1 [Target identity:100%; Query identity:100%]
LIM domain only 3 (Rhombotin-like 2), isoform CRA_b
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:2000324 [positive regulation of glucocorticoid receptor signaling pathway]
Show all
 145 aa
16.6 kDa 		No 0
LMO3-013
ENSP00000446115
ENST00000535535
Q8TAP4 [Direct mapping]
LIM domain only protein 3
A0A024RAT1 [Target identity:100%; Query identity:100%]
LIM domain only 3 (Rhombotin-like 2), isoform CRA_b
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:2000324 [positive regulation of glucocorticoid receptor signaling pathway]
Show all
 145 aa
16.6 kDa 		No 0
LMO3-014
ENSP00000312856
ENST00000320122
Q8TAP4 [Direct mapping]
LIM domain only protein 3
A0A024RAT1 [Target identity:100%; Query identity:100%]
LIM domain only 3 (Rhombotin-like 2), isoform CRA_b
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:2000324 [positive regulation of glucocorticoid receptor signaling pathway]
Show all
 145 aa
16.6 kDa 		No 0
LMO3-016
ENSP00000444393
ENST00000541846
Q8TAP4 [Direct mapping]
LIM domain only protein 3
A0A024RAT1 [Target identity:100%; Query identity:100%]
LIM domain only 3 (Rhombotin-like 2), isoform CRA_b
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:2000324 [positive regulation of glucocorticoid receptor signaling pathway]
Show all
 145 aa
16.6 kDa 		No 0
LMO3-019
ENSP00000439989
ENST00000540590
F5H4T0 [Direct mapping]
LIM domain only protein 3
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Predicted intracellular proteins
Show all
GO:0008270 [zinc ion binding]
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 84 aa
9.4 kDa 		No 0
LMO3-020
ENSP00000439275
ENST00000534946
Q8TAP4 [Direct mapping]
LIM domain only protein 3
A0A024RAT1 [Target identity:100%; Query identity:100%]
LIM domain only 3 (Rhombotin-like 2), isoform CRA_b
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:2000324 [positive regulation of glucocorticoid receptor signaling pathway]
Show all
 145 aa
16.6 kDa 		No 0
LMO3-021
ENSP00000441360
ENST00000546279
F5GYZ6 [Direct mapping]
LIM domain only protein 3
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Predicted intracellular proteins
Show all
GO:0008270 [zinc ion binding]
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 110 aa
12.5 kDa 		No 0
LMO3-022
ENSP00000445504
ENST00000538051
F5H2N9 [Direct mapping]
LIM domain only protein 3
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Predicted intracellular proteins
Show all
GO:0008270 [zinc ion binding]
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 97 aa
10.9 kDa 		No 0
LMO3-024
ENSP00000445193
ENST00000537757
F5H3S4 [Direct mapping]
LIM domain only protein 3
Show all
Predicted intracellular proteins
Show all
GO:0008270 [zinc ion binding]
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 118 aa
13.4 kDa 		No 0
LMO3-025
ENSP00000442713
ENST00000546281
F5H3S4 [Direct mapping]
LIM domain only protein 3
Show all
Predicted intracellular proteins
Show all
GO:0008270 [zinc ion binding]
Show all
 118 aa
13.4 kDa 		No 0
LMO3-029
ENSP00000444269
ENST00000545436
F5GZR3 [Direct mapping]
LIM domain only protein 3
Show all
Predicted intracellular proteins
Show all
GO:0008270 [zinc ion binding]
Show all
 88 aa
9.9 kDa 		No 0
LMO3-030
ENSP00000446095
ENST00000538020
F5H4K9 [Direct mapping]
LIM domain only protein 3
Show all
Predicted intracellular proteins
Show all
GO:0008270 [zinc ion binding]
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 58 aa
6.5 kDa 		No 0
LMO3-031
ENSP00000443807
ENST00000539534
F5H3S4 [Direct mapping]
LIM domain only protein 3
Show all
Predicted intracellular proteins
Show all
GO:0008270 [zinc ion binding]
Show all
 118 aa
13.4 kDa 		No 0
LMO3-201
ENSP00000261169
ENST00000261169
Q8TAP4 [Direct mapping]
LIM domain only protein 3
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:2000324 [positive regulation of glucocorticoid receptor signaling pathway]
Show all
 156 aa
17.9 kDa 		No 0
LMO3-202
ENSP00000346689
ENST00000354662
Q8TAP4 [Direct mapping]
LIM domain only protein 3
A0A024RAT1 [Target identity:100%; Query identity:100%]
LIM domain only 3 (Rhombotin-like 2), isoform CRA_b
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:2000324 [positive regulation of glucocorticoid receptor signaling pathway]
Show all
 145 aa
16.6 kDa 		No 0
LMO3-203
ENSP00000446463
ENST00000541295
Q8TAP4 [Direct mapping]
LIM domain only protein 3
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0035360 [positive regulation of peroxisome proliferator activated receptor signaling pathway]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:2000324 [positive regulation of glucocorticoid receptor signaling pathway]
Show all
 163 aa
18.4 kDa 		No 0
LMO3-204
ENSP00000481643
ENST00000616247
A0A087WYA2 [Direct mapping]
LIM domain only protein 3
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Predicted intracellular proteins
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GO:0008270 [zinc ion binding]
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 125 aa
14.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.