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GUCA1A

GENERAL INFORMATION

Gene name

 GUCA1A

Gene description

 Guanylate cyclase activator 1A (retina)

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Group enriched (NTERA-2, SH-SY5Y)
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in retina, mainly in photoreceptor layer.

ANTIBODY IHC RELIABILITY

Data reliability
description

 External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 1 antibody.
HPA005561
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005561

GENE INFORMATION

Gene name

 GUCA1A (HGNC Symbol)

Synonyms

 C6orf131, COD3, CORD14, dJ139D8.6, GCAP, GCAP1, GUCA, GUCA1

Description

 Guanylate cyclase activator 1A (retina) (HGNC Symbol)

Entrez gene summary

 This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. [provided by RefSeq, Feb 2009]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 42155406 - 42180056

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000048545 (version 83.38)

Entrez gene

 2978

UniProt

 P43080 (UniProt - Evidence at protein level)

neXtProt

 NX_P43080

Antibodypedia

 GUCA1A antibodies

PROTEIN BROWSER
GUCA1A-001
GUCA1A-002
GUCA1A-003
GUCA1A-004
GUCA1A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GUCA1A-001
ENSP00000362049
ENST00000372958
P43080 [Direct mapping]
Guanylyl cyclase-activating protein 1
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Predicted intracellular proteins
Disease related genes
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GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007603 [phototransduction, visible light]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0097381 [photoreceptor disc membrane]
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 201 aa
22.9 kDa 		No 0
GUCA1A-002
ENSP00000377784
ENST00000394237
P43080 [Direct mapping]
Guanylyl cyclase-activating protein 1
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Predicted intracellular proteins
Disease related genes
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GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007601 [visual perception]
GO:0007602 [phototransduction]
GO:0007603 [phototransduction, visible light]
GO:0008048 [calcium sensitive guanylate cyclase activator activity]
GO:0016020 [membrane]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0030249 [guanylate cyclase regulator activity]
GO:0030828 [positive regulation of cGMP biosynthetic process]
GO:0031282 [regulation of guanylate cyclase activity]
GO:0031284 [positive regulation of guanylate cyclase activity]
GO:0097381 [photoreceptor disc membrane]
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 201 aa
22.9 kDa 		No 0
GUCA1A-003
ENSP00000053469
ENST00000053469
P43080 [Direct mapping]
Guanylyl cyclase-activating protein 1
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007603 [phototransduction, visible light]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0097381 [photoreceptor disc membrane]
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 201 aa
22.9 kDa 		No 0
GUCA1A-004
ENSP00000388438
ENST00000418175
A6PVH5 [Direct mapping]
Guanylyl cyclase-activating protein 1
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Predicted intracellular proteins
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GO:0005509 [calcium ion binding]
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 88 aa
10.2 kDa 		No 0
GUCA1A-201
ENSP00000437476
ENST00000541991
A0A0A0MTF5 [Direct mapping]
Guanylyl cyclase-activating protein 1
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Predicted intracellular proteins
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GO:0005509 [calcium ion binding]
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 205 aa
23.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.