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Cytoplasmic and nuclear expression mainly in peripheral leukocytes, hematopoietic cells and cells in splenic red pulp.
ANTIBODY IHC RELIABILITY
Data reliability description
Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Weak to moderate cytoplasmic and nuclear staining was observed in prostate cancer. Several cases of breast and skin cancers showed weak nuclear positivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
KITLG (HGNC Symbol)
Synonyms
FPH2, Kitl, KL-1, MGF, SCF, SF
Description
KIT ligand (HGNC Symbol)
Entrez gene summary
This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]