Expression of LTBP1 in cancer - Summary - The Human Protein Atlas

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LTBP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LTBP1
Gene description	Latent transforming growth factor beta binding protein 1
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, U-87 MG)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression and extracellular positivity in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. CAB025428
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB025428

GENE INFORMATION
Gene name	LTBP1
Synonyms
Description	Latent transforming growth factor beta binding protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p22.3
Chromosome location (bp)	32946972 - 33399509
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000049323 (version 83.38)
Entrez gene	4052
UniProt	Q14766 (UniProt - Evidence at protein level)
neXtProt	NX_Q14766
Antibodypedia	LTBP1 antibodies

PROTEIN BROWSER

LTBP1-001	LTBP1-006	LTBP1-007	LTBP1-008	LTBP1-010	LTBP1-014	LTBP1-016	LTBP1-017	LTBP1-018	LTBP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LTBP1-001 ENSP00000385359 ENST00000404525	Q14766 [Direct mapping] Latent-transforming growth factor beta-binding protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] GO:0005024 [transforming growth factor beta-activated receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0035583 [sequestering of TGFbeta in extracellular matrix] GO:0043234 [protein complex] GO:0050431 [transforming growth factor beta binding] GO:0050436 [microfibril binding] Show all	1342 aa 147.2 kDa	Yes	0
LTBP1-006 ENSP00000415412 ENST00000413303	C9JDW2 [Direct mapping] Latent-transforming growth factor beta-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		219 aa 23.2 kDa	No	0
LTBP1-007 ENSP00000384091 ENST00000407925	Q14766 [Direct mapping] Latent-transforming growth factor beta-binding protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] GO:0005024 [transforming growth factor beta-activated receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0035583 [sequestering of TGFbeta in extracellular matrix] GO:0043234 [protein complex] GO:0050431 [transforming growth factor beta binding] GO:0050436 [microfibril binding] Show all	1395 aa 152.9 kDa	Yes	0
LTBP1-008 ENSP00000384373 ENST00000402934	C9JD84 [Direct mapping] Latent-transforming growth factor beta-binding protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	1340 aa 147 kDa	Yes	0
LTBP1-010 ENSP00000395211 ENST00000422669	H7C0I7 [Direct mapping] Latent-transforming growth factor beta-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	270 aa 29.3 kDa	No	0
LTBP1-014 ENSP00000386043 ENST00000404816	Q14766 [Direct mapping] Latent-transforming growth factor beta-binding protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001527 [microfibril] GO:0003281 [ventricular septum development] GO:0005024 [transforming growth factor beta-activated receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0035583 [sequestering of TGFbeta in extracellular matrix] GO:0035904 [aorta development] GO:0043234 [protein complex] GO:0050431 [transforming growth factor beta binding] GO:0050436 [microfibril binding] GO:0060976 [coronary vasculature development] Show all	1721 aa 186.8 kDa	Yes	0
LTBP1-016 ENSP00000405993 ENST00000432635	H7C2H7 [Direct mapping] Latent-transforming growth factor beta-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	101 aa 10.9 kDa	No	0
LTBP1-017 ENSP00000388154 ENST00000415140	H7BZ76 [Direct mapping] Latent-transforming growth factor beta-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	267 aa 28.8 kDa	No	0
LTBP1-018 ENSP00000417591 ENST00000468091	H7C4L5 [Direct mapping] Latent-transforming growth factor beta-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		221 aa 23.5 kDa	No	0
LTBP1-201 ENSP00000393057 ENST00000418533	E7EV71 [Direct mapping] Latent-transforming growth factor beta-binding protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	1353 aa 148.4 kDa	Yes	0

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