Expression of RCN1 in cancer - Summary - The Human Protein Atlas

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RCN1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RCN1
Gene description	Reticulocalbin 1, EF-hand calcium binding domain
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA038474 , HPA062104
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038474	HPA062104

GENE INFORMATION
Gene name	RCN1 (HGNC Symbol)
Synonyms	FLJ37041, PIG20, Rcal, RCN
Description	Reticulocalbin 1, EF-hand calcium binding domain (HGNC Symbol)
Entrez gene summary	Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.[provided by RefSeq, Jan 2009]
Chromosome	11
Cytoband	p13
Chromosome location (bp)	31812391 - 32105755
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000049449 (version 83.38)
Entrez gene	5954
UniProt	Q15293 (UniProt - Evidence at protein level)
neXtProt	NX_Q15293
Antibodypedia	RCN1 antibodies

PROTEIN BROWSER

RCN1-001	RCN1-002	RCN1-005	RCN1-008	RCN1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RCN1-001 ENSP00000436422 ENST00000532942	Q15293 [Direct mapping] Reticulocalbin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] Show all	280 aa 33 kDa	No	0
RCN1-002 ENSP00000054950 ENST00000054950	Q15293 [Direct mapping] Reticulocalbin-1 V9HW95 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 84 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0043010 [camera-type eye development] Show all	331 aa 38.9 kDa	Yes	0
RCN1-005 ENSP00000433249 ENST00000532721	E9PLM2 [Direct mapping] Reticulocalbin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		20 aa 2.3 kDa	No	0
RCN1-008 ENSP00000433237 ENST00000528630	H0YDA4 [Direct mapping] Reticulocalbin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		28 aa 3.3 kDa	No	0
RCN1-013 ENSP00000436482 ENST00000530348	E9PP27 [Direct mapping] Reticulocalbin-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	58 aa 6.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.