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LIMA1

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GENERAL INFORMATION

Gene name

 LIMA1

Gene description

 LIM domain and actin binding 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the plasma membrane & actin filaments. In addition localized to the cytosol & focal adhesion sites.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Plasma membrane (validated), Actin filaments (validated)

Additional location

 In addition localized to the Focal adhesion sites (validated), Cytosol (validated)

Mouse

 Localized to the Plasma membrane, Actin filaments in mouse cells.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA023871 , HPA052645
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the plasma membrane & actin filaments. In addition localized to the cytosol & focal adhesion sites.

Main location

 Plasma membrane (validated), Actin filaments (validated)

Additional location

 Focal adhesion sites (validated), Cytosol (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA023871 A-431 Plasma membrane
Actin filaments
Cytosol
HPA023871 U-2 OS Plasma membrane
Actin filaments
Cytosol
HPA023871 U-251 MG Plasma membrane
Cytosol
HPA052645 A-431 Plasma membrane
Actin filaments
HPA052645 U-2 OS Plasma membrane
Actin filaments
Focal adhesion sites
HPA052645 U-251 MG Plasma membrane
Focal adhesion sites

MOUSE CELLS

Main location

 Plasma membrane, Actin filaments

Mouse gene

 ENSMUSG00000023022 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA052645 NIH 3T3 Plasma membrane
Actin filaments

GENE INFORMATION

Gene name

 LIMA1 (HGNC Symbol)

Synonyms

 EPLIN

Description

 LIM domain and actin binding 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 50175788 - 50283546

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000050405 (version 83.38)

Entrez gene

 51474

UniProt

 Q9UHB6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHB6

Antibodypedia

 LIMA1 antibodies

PROTEIN BROWSER
LIMA1-001
LIMA1-002
LIMA1-003
LIMA1-004
LIMA1-006
LIMA1-007
LIMA1-008
LIMA1-009
LIMA1-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LIMA1-001
ENSP00000378400
ENST00000394943
Q9UHB6 [Direct mapping]
LIM domain and actin-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003785 [actin monomer binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030835 [negative regulation of actin filament depolymerization]
GO:0031529 [ruffle organization]
GO:0032154 [cleavage furrow]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
Show all
 760 aa
85.2 kDa 		No 0
LIMA1-002
ENSP00000448779
ENST00000552783
Q9UHB6 [Direct mapping]
LIM domain and actin-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003785 [actin monomer binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030835 [negative regulation of actin filament depolymerization]
GO:0031529 [ruffle organization]
GO:0032154 [cleavage furrow]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
Show all
 600 aa
67.1 kDa 		No 0
LIMA1-003
ENSP00000340184
ENST00000341247
Q9UHB6 [Direct mapping]
LIM domain and actin-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003785 [actin monomer binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030835 [negative regulation of actin filament depolymerization]
GO:0031529 [ruffle organization]
GO:0032154 [cleavage furrow]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
Show all
 759 aa
85.2 kDa 		No 0
LIMA1-004
ENSP00000450087
ENST00000552909
F8VQE1 [Direct mapping]
LIM domain and actin-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
Show all
 598 aa
67 kDa 		No 0
LIMA1-006
ENSP00000450266
ENST00000552823
Q9UHB6 [Direct mapping]
LIM domain and actin-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003785 [actin monomer binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030835 [negative regulation of actin filament depolymerization]
GO:0031529 [ruffle organization]
GO:0032154 [cleavage furrow]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
Show all
 599 aa
67.1 kDa 		No 0
LIMA1-007
ENSP00000448706
ENST00000547825
Q9UHB6 [Direct mapping]
LIM domain and actin-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003785 [actin monomer binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030835 [negative regulation of actin filament depolymerization]
GO:0031529 [ruffle organization]
GO:0032154 [cleavage furrow]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
Show all
 457 aa
51.2 kDa 		No 0
LIMA1-008
ENSP00000449890
ENST00000550592
F8VVQ7 [Direct mapping]
LIM domain and actin-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 111 aa
12.7 kDa 		No 0
LIMA1-009
ENSP00000447975
ENST00000551691
F8VTU2 [Direct mapping]
LIM domain and actin-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 130 aa
14.7 kDa 		No 0
LIMA1-017
ENSP00000448463
ENST00000552491
F8VS07 [Direct mapping]
LIM domain and actin-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
Show all
 456 aa
51.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.