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LIMA1

GENERAL INFORMATION

Gene name

 LIMA1

Gene description

 LIM domain and actin binding 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Plasma membrane expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA023871 , HPA052645
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable) and renal cancer (favourable).
Head and neck cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023871
HPA052645

GENE INFORMATION

Gene name

 LIMA1 (HGNC Symbol)

Synonyms

 EPLIN

Description

 LIM domain and actin binding 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 50175788 - 50283546

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000050405 (version 83.38)

Entrez gene

 51474

UniProt

 Q9UHB6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHB6

Antibodypedia

 LIMA1 antibodies

PROTEIN BROWSER
LIMA1-001
LIMA1-002
LIMA1-003
LIMA1-004
LIMA1-006
LIMA1-007
LIMA1-008
LIMA1-009
LIMA1-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LIMA1-001
ENSP00000378400
ENST00000394943
Q9UHB6 [Direct mapping]
LIM domain and actin-binding protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003785 [actin monomer binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005903 [brush border]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030835 [negative regulation of actin filament depolymerization]
GO:0031529 [ruffle organization]
GO:0032154 [cleavage furrow]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
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 760 aa
85.2 kDa 		No 0
LIMA1-002
ENSP00000448779
ENST00000552783
Q9UHB6 [Direct mapping]
LIM domain and actin-binding protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003785 [actin monomer binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030835 [negative regulation of actin filament depolymerization]
GO:0031529 [ruffle organization]
GO:0032154 [cleavage furrow]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
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 600 aa
67.1 kDa 		No 0
LIMA1-003
ENSP00000340184
ENST00000341247
Q9UHB6 [Direct mapping]
LIM domain and actin-binding protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003785 [actin monomer binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030835 [negative regulation of actin filament depolymerization]
GO:0031529 [ruffle organization]
GO:0032154 [cleavage furrow]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
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 759 aa
85.2 kDa 		No 0
LIMA1-004
ENSP00000450087
ENST00000552909
F8VQE1 [Direct mapping]
LIM domain and actin-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
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 598 aa
67 kDa 		No 0
LIMA1-006
ENSP00000450266
ENST00000552823
Q9UHB6 [Direct mapping]
LIM domain and actin-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003785 [actin monomer binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030835 [negative regulation of actin filament depolymerization]
GO:0031529 [ruffle organization]
GO:0032154 [cleavage furrow]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
Show all
 599 aa
67.1 kDa 		No 0
LIMA1-007
ENSP00000448706
ENST00000547825
Q9UHB6 [Direct mapping]
LIM domain and actin-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003785 [actin monomer binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
GO:0030835 [negative regulation of actin filament depolymerization]
GO:0031529 [ruffle organization]
GO:0032154 [cleavage furrow]
GO:0051015 [actin filament binding]
GO:0051017 [actin filament bundle assembly]
Show all
 457 aa
51.2 kDa 		No 0
LIMA1-008
ENSP00000449890
ENST00000550592
F8VVQ7 [Direct mapping]
LIM domain and actin-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 111 aa
12.7 kDa 		No 0
LIMA1-009
ENSP00000447975
ENST00000551691
F8VTU2 [Direct mapping]
LIM domain and actin-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 130 aa
14.7 kDa 		No 0
LIMA1-017
ENSP00000448463
ENST00000552491
F8VS07 [Direct mapping]
LIM domain and actin-binding protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0008270 [zinc ion binding]
GO:0015629 [actin cytoskeleton]
Show all
 456 aa
51.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.