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SLC4A8

GENERAL INFORMATION

Gene name

 SLC4A8

Gene description

 Solute carrier family 4, sodium bicarbonate cotransporter, member 8

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (breast cancer, glioma, testis cancer)
HPA (cell line):Cell line enhanced (BEWO, SCLC-21H)
HPA (normal tissue):Tissue enhanced (cerebral cortex, testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (breast cancer, glioma, testis cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SLC4A8 (HGNC Symbol)

Synonyms

 NBC3

Description

 Solute carrier family 4, sodium bicarbonate cotransporter, member 8 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 51391317 - 51515763

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000050438 (version 83.38)

Entrez gene

 9498

UniProt

 Q2Y0W8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q2Y0W8

Antibodypedia

 SLC4A8 antibodies

PROTEIN BROWSER
SLC4A8-001
SLC4A8-003
SLC4A8-016
SLC4A8-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC4A8-001
ENSP00000405812
ENST00000453097
Q2Y0W8 [Direct mapping]
Electroneutral sodium bicarbonate exchanger 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0032809 [neuronal cell body membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0043005 [neuron projection]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0098656 [anion transmembrane transport]
Show all
 1093 aa
122.9 kDa 		No >9
SLC4A8-003
ENSP00000442561
ENST00000514353
Q2Y0W8 [Direct mapping]
Electroneutral sodium bicarbonate exchanger 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0098656 [anion transmembrane transport]
Show all
 747 aa
84 kDa 		No 6
SLC4A8-016
ENSP00000441520
ENST00000535225
Q2Y0W8 [Direct mapping]
Electroneutral sodium bicarbonate exchanger 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0098656 [anion transmembrane transport]
Show all
 638 aa
71.3 kDa 		No 4
SLC4A8-201
ENSP00000351483
ENST00000358657
Q2Y0W8 [Direct mapping]
Electroneutral sodium bicarbonate exchanger 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005452 [inorganic anion exchanger activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006820 [anion transport]
GO:0008509 [anion transmembrane transporter activity]
GO:0008510 [sodium:bicarbonate symporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:0098656 [anion transmembrane transport]
Show all
 1040 aa
117.1 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.