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HOMER3

GENERAL INFORMATION

Gene name

 HOMER3

Gene description

 Homer scaffolding protein 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct cytoplasmic expression in Purkinje cells and lymphatic endothelial cells in spleen.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 2 antibodies.
HPA040999 , CAB032656
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable) and liver cancer (unfavourable).
Colorectal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040999
CAB032656

GENE INFORMATION

Gene name

 HOMER3 (HGNC Symbol)

Synonyms

 HOMER-3

Description

 Homer scaffolding protein 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 18929201 - 18941261

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000051128 (version 83.38)

Entrez gene

 9454

UniProt

 Q9NSC5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NSC5

Antibodypedia

 HOMER3 antibodies

PROTEIN BROWSER
HOMER3-001
HOMER3-002
HOMER3-003
HOMER3-004
HOMER3-005
HOMER3-006
HOMER3-007
HOMER3-008
HOMER3-010
HOMER3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HOMER3-001
ENSP00000376162
ENST00000392351
Q9NSC5 [Direct mapping]
Homer protein homolog 3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006605 [protein targeting]
GO:0007216 [G-protein coupled glutamate receptor signaling pathway]
GO:0030054 [cell junction]
GO:0035256 [G-protein coupled glutamate receptor binding]
GO:0045211 [postsynaptic membrane]
GO:0097481 [neuronal postsynaptic density]
GO:2001256 [regulation of store-operated calcium entry]
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 361 aa
39.8 kDa 		No 0
HOMER3-002
ENSP00000221222
ENST00000221222
Q9NSC5 [Direct mapping]
Homer protein homolog 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006605 [protein targeting]
GO:0007216 [G-protein coupled glutamate receptor signaling pathway]
GO:0030054 [cell junction]
GO:0035256 [G-protein coupled glutamate receptor binding]
GO:0045211 [postsynaptic membrane]
GO:0097481 [neuronal postsynaptic density]
GO:2001256 [regulation of store-operated calcium entry]
Show all
 358 aa
39.5 kDa 		No 0
HOMER3-003
ENSP00000471835
ENST00000594439
Q9NSC5 [Direct mapping]
Homer protein homolog 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006605 [protein targeting]
GO:0007216 [G-protein coupled glutamate receptor signaling pathway]
GO:0030054 [cell junction]
GO:0035256 [G-protein coupled glutamate receptor binding]
GO:0045211 [postsynaptic membrane]
GO:0097481 [neuronal postsynaptic density]
GO:2001256 [regulation of store-operated calcium entry]
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 325 aa
36 kDa 		No 0
HOMER3-004
ENSP00000439937
ENST00000539827
Q9NSC5 [Direct mapping]
Homer protein homolog 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006605 [protein targeting]
GO:0007216 [G-protein coupled glutamate receptor signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0014069 [postsynaptic density]
GO:0019904 [protein domain specific binding]
GO:0030054 [cell junction]
GO:0035256 [G-protein coupled glutamate receptor binding]
GO:0045178 [basal part of cell]
GO:0045211 [postsynaptic membrane]
GO:0097481 [neuronal postsynaptic density]
GO:2001256 [regulation of store-operated calcium entry]
Show all
 361 aa
39.8 kDa 		No 0
HOMER3-005
ENSP00000446026
ENST00000542541
Q9NSC5 [Direct mapping]
Homer protein homolog 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006605 [protein targeting]
GO:0007216 [G-protein coupled glutamate receptor signaling pathway]
GO:0030054 [cell junction]
GO:0035256 [G-protein coupled glutamate receptor binding]
GO:0045211 [postsynaptic membrane]
GO:0097481 [neuronal postsynaptic density]
GO:2001256 [regulation of store-operated calcium entry]
Show all
 361 aa
39.8 kDa 		No 0
HOMER3-006
ENSP00000469800
ENST00000594794
M0QYF9 [Direct mapping]
Homer protein homolog 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0035256 [G-protein coupled glutamate receptor binding]
GO:0097481 [neuronal postsynaptic density]
GO:2001256 [regulation of store-operated calcium entry]
Show all
 152 aa
17 kDa 		No 0
HOMER3-007
ENSP00000472800
ENST00000599097
M0R2T8 [Direct mapping]
Homer protein homolog 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0035256 [G-protein coupled glutamate receptor binding]
GO:0097481 [neuronal postsynaptic density]
GO:2001256 [regulation of store-operated calcium entry]
Show all
 85 aa
9.5 kDa 		No 0
HOMER3-008
ENSP00000470659
ENST00000600077
M0QZN1 [Direct mapping]
Homer protein homolog 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0035256 [G-protein coupled glutamate receptor binding]
GO:0097481 [neuronal postsynaptic density]
GO:2001256 [regulation of store-operated calcium entry]
Show all
 150 aa
16.3 kDa 		No 0
HOMER3-010
ENSP00000472815
ENST00000596482
M0R2U7 [Direct mapping]
Homer protein homolog 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0035256 [G-protein coupled glutamate receptor binding]
GO:0097481 [neuronal postsynaptic density]
GO:2001256 [regulation of store-operated calcium entry]
Show all
 243 aa
26.7 kDa 		No 0
HOMER3-201
ENSP00000396154
ENST00000433218
Q9NSC5 [Direct mapping]
Homer protein homolog 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006605 [protein targeting]
GO:0007216 [G-protein coupled glutamate receptor signaling pathway]
GO:0030054 [cell junction]
GO:0035256 [G-protein coupled glutamate receptor binding]
GO:0045211 [postsynaptic membrane]
GO:0097481 [neuronal postsynaptic density]
GO:2001256 [regulation of store-operated calcium entry]
Show all
 358 aa
39.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.