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PIK3CB

GENERAL INFORMATION

Gene name

 PIK3CB

Gene description

 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB031938
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and liver cancer (unfavourable).
Pancreatic cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB031938

GENE INFORMATION

Gene name

 PIK3CB (HGNC Symbol)

Synonyms

 PIK3C1

Description

 Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta (HGNC Symbol)

Entrez gene summary

 This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Chromosome

 3

Cytoband

 q22.3

Chromosome location (bp)

 138652699 - 138834938

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000051382 (version 83.38)

Entrez gene

 5291

UniProt

 P42338 (UniProt - Evidence at protein level)

neXtProt

 NX_P42338

Antibodypedia

 PIK3CB antibodies

PROTEIN BROWSER
PIK3CB-001
PIK3CB-003
PIK3CB-004
PIK3CB-007
PIK3CB-008
PIK3CB-014
PIK3CB-201
PIK3CB-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PIK3CB-001
ENSP00000418143
ENST00000477593
P42338 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001952 [regulation of cell-matrix adhesion]
GO:0002250 [adaptive immune response]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006914 [autophagy]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010508 [positive regulation of autophagy]
GO:0010628 [positive regulation of gene expression]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016477 [cell migration]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030168 [platelet activation]
GO:0035004 [phosphatidylinositol 3-kinase activity]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0060326 [cell chemotaxis]
GO:0070527 [platelet aggregation]
GO:2000369 [regulation of clathrin-mediated endocytosis]
Show all
 1070 aa
122.8 kDa 		No 0
PIK3CB-003
ENSP00000420399
ENST00000461451
C9JNF6 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060326 [cell chemotaxis]
Show all
 100 aa
11.6 kDa 		No 0
PIK3CB-004
ENSP00000417869
ENST00000493568
H0Y871 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060326 [cell chemotaxis]
Show all
 702 aa
80.4 kDa 		No 0
PIK3CB-007
ENSP00000419857
ENST00000483968
C9JYX0 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060326 [cell chemotaxis]
Show all
 131 aa
14.9 kDa 		No 0
PIK3CB-008
ENSP00000417329
ENST00000465581
C9J345 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060326 [cell chemotaxis]
Show all
 56 aa
6.2 kDa 		No 0
PIK3CB-014
ENSP00000418834
ENST00000462294
H7C527 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060326 [cell chemotaxis]
Show all
 181 aa
20.9 kDa 		No 0
PIK3CB-201
ENSP00000289153
ENST00000289153
P42338 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001935 [endothelial cell proliferation]
GO:0001952 [regulation of cell-matrix adhesion]
GO:0002250 [adaptive immune response]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006644 [phospholipid metabolic process]
GO:0006661 [phosphatidylinositol biosynthetic process]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006914 [autophagy]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009611 [response to wounding]
GO:0010508 [positive regulation of autophagy]
GO:0010628 [positive regulation of gene expression]
GO:0014065 [phosphatidylinositol 3-kinase signaling]
GO:0016303 [1-phosphatidylinositol-3-kinase activity]
GO:0016477 [cell migration]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0030168 [platelet activation]
GO:0035004 [phosphatidylinositol 3-kinase activity]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0040016 [embryonic cleavage]
GO:0043560 [insulin receptor substrate binding]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0060055 [angiogenesis involved in wound healing]
GO:0060326 [cell chemotaxis]
GO:0070527 [platelet aggregation]
GO:2000369 [regulation of clathrin-mediated endocytosis]
Show all
 1070 aa
122.8 kDa 		No 0
PIK3CB-202
ENSP00000438259
ENST00000544716
Q68DL0 [Direct mapping]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Putative uncharacterized protein DKFZp779K1237
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0005488 [binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005942 [phosphatidylinositol 3-kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006954 [inflammatory response]
GO:0016773 [phosphotransferase activity, alcohol group as acceptor]
GO:0035005 [1-phosphatidylinositol-4-phosphate 3-kinase activity]
GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process]
GO:0045087 [innate immune response]
GO:0046854 [phosphatidylinositol phosphorylation]
GO:0046934 [phosphatidylinositol-4,5-bisphosphate 3-kinase activity]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0060326 [cell chemotaxis]
Show all
 521 aa
59.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.