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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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FNIP2
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

FNIP2

Gene description

Folliculin interacting protein 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HDLM-2)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA042779
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA042779

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Tumour cells showed weak to moderate cytoplasmic staining. Prostate cancers exhibited strong positivity. A majority of gliomas, lymphomas, melanomas as well as lung, endometrial and skin cancers were negative.

GENE INFORMATION

Gene name

FNIP2 (HGNC Symbol)

Synonyms

FNIPL, KIAA1450, MAPO1

Description

Folliculin interacting protein 2 (HGNC Symbol)

Entrez gene summary

Chromosome

4

Cytoband

q32.1

Chromosome location (bp)

158769138 - 158908049

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000052795 (version 83.38)

Entrez gene

57600

UniProt

Q9P278 (UniProt - Evidence at protein level)

neXtProt

NX_Q9P278

Antibodypedia

FNIP2 antibodies

PROTEIN BROWSER

FNIP2-001
FNIP2-004
FNIP2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FNIP2-001
ENSP00000264433
ENST00000264433
Q9P278 [Direct mapping]
Folliculin-interacting protein 2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001932 [regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005815 [microtubule organizing center]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0031334 [positive regulation of protein complex assembly]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
Show all
1114 aa
122.1 kDa
No 0
FNIP2-004
ENSP00000421488
ENST00000512986
D6RFH5 [Direct mapping]
Folliculin-interacting protein 2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
673 aa
74.7 kDa
No 0
FNIP2-005
ENSP00000420841
ENST00000504715
H0Y8F3 [Direct mapping]
Folliculin-interacting protein 2
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Predicted intracellular proteins
Show all
241 aa
26.7 kDa
No 0

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