Expression of MSMO1 in cancer - Summary - The Human Protein Atlas

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MSMO1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MSMO1
Gene description	Methylsterol monooxygenase 1
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types, including liver.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA056127
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable) and renal cancer (favourable).
Cervical cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056127

GENE INFORMATION
Gene name	MSMO1 (HGNC Symbol)
Synonyms	DESP4, ERG25, SC4MOL
Description	Methylsterol monooxygenase 1 (HGNC Symbol)
Entrez gene summary	Sterol-C4-mehtyl oxidase-like protein was isolated based on its similarity to the yeast ERG25 protein. It contains a set of putative metal binding motifs with similarity to that seen in a family of membrane desaturases-hydroxylases. The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q32.3
Chromosome location (bp)	165327623 - 165343160
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000052802 (version 83.38)
Entrez gene	6307
UniProt	Q15800 (UniProt - Evidence at protein level)
neXtProt	NX_Q15800
Antibodypedia	MSMO1 antibodies

PROTEIN BROWSER

MSMO1-001	MSMO1-002	MSMO1-003	MSMO1-004	MSMO1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MSMO1-001 ENSP00000261507 ENST00000261507	Q15800 [Direct mapping] Methylsterol monooxygenase 1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000254 [C-4 methylsterol oxidase activity] GO:0005506 [iron ion binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006631 [fatty acid metabolic process] GO:0006633 [fatty acid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0008202 [steroid metabolic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	293 aa 35.2 kDa	No	4
MSMO1-002 ENSP00000377361 ENST00000393766	Q15800 [Direct mapping] Methylsterol monooxygenase 1 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000254 [C-4 methylsterol oxidase activity] GO:0005506 [iron ion binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006631 [fatty acid metabolic process] GO:0006633 [fatty acid biosynthetic process] GO:0006695 [cholesterol biosynthetic process] GO:0008202 [steroid metabolic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	162 aa 19.5 kDa	No	1
MSMO1-003 ENSP00000423633 ENST00000504317	D6R952 [Direct mapping] Methylsterol monooxygenase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0006633 [fatty acid biosynthetic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	229 aa 27.6 kDa	No	4
MSMO1-004 ENSP00000425241 ENST00000507013	D6RDP9 [Direct mapping] Methylsterol monooxygenase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005506 [iron ion binding] GO:0006633 [fatty acid biosynthetic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	220 aa 26.5 kDa	No	4
MSMO1-005 ENSP00000425112 ENST00000505270	D6REA2 [Direct mapping] Methylsterol monooxygenase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	85 aa 9.9 kDa	No	1

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The Human Protein Atlas

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