Cell atlas - MRTO4 - The Human Protein Atlas

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MRTO4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nucleoli
	Nucleus

Human cell
	Nuclear membrane
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MRTO4
Gene description	MRT4 homolog, ribosome maturation factor
Protein class	Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus & nuclear membrane. In addition localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved), Nuclear membrane (approved)
Additional location	In addition localized to the Nucleoli (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA026446
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus & nuclear membrane. In addition localized to the nucleoli.

Main location

Nucleus (approved), Nuclear membrane (approved)

Additional location

Nucleoli (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA026446	A-431	Nucleus
	HPA026446	A-431	Nuclear membrane
	HPA026446	U-2 OS	Nucleus	Intensity
			Nuclear membrane
			Nucleoli	Intensity
	HPA026446	U-251 MG	Nucleus
	HPA026446	U-251 MG	Nuclear membrane

GENE INFORMATION
Gene name	MRTO4 (HGNC Symbol)
Synonyms	C1orf33, dJ657E11.4, MRT4
Description	MRT4 homolog, ribosome maturation factor (HGNC Symbol)
Entrez gene summary	This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.13
Chromosome location (bp)	19251539 - 19260128
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000053372 (version 83.38)
Entrez gene	51154
UniProt	Q9UKD2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UKD2
Antibodypedia	MRTO4 antibodies

PROTEIN BROWSER

MRTO4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRTO4-001 ENSP00000364320 ENST00000330263	Q9UKD2 [Direct mapping] mRNA turnover protein 4 homolog A0A024RAE1 [Target identity:100%; Query identity:100%] Chromosome 1 open reading frame 33, isoform CRA_a Show all	Ribosomal proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0031965 [nuclear membrane] GO:0042254 [ribosome biogenesis] GO:0044822 [poly(A) RNA binding] Show all	239 aa 27.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.