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ANAPC4

GENERAL INFORMATION

Gene name

 ANAPC4

Gene description

 Anaphase promoting complex subunit 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA038395 , HPA038396 , CAB032519
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), urothelial cancer (favourable), renal cancer (unfavourable) and head and neck cancer (favourable).
Endometrial cancer p<0.001
Urothelial cancer p<0.001
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA038395
HPA038396
CAB032519

GENE INFORMATION

Gene name

 ANAPC4 (HGNC Symbol)

Synonyms

 APC4

Description

 Anaphase promoting complex subunit 4 (HGNC Symbol)

Entrez gene summary

 A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Chromosome

 4

Cytoband

 p15.2

Chromosome location (bp)

 25377213 - 25418498

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000053900 (version 83.38)

Entrez gene

 29945

UniProt

 Q9UJX5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UJX5

Antibodypedia

 ANAPC4 antibodies

PROTEIN BROWSER
ANAPC4-001
ANAPC4-002
ANAPC4-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANAPC4-001
ENSP00000318775
ENST00000315368
Q9UJX5 [Direct mapping]
Anaphase-promoting complex subunit 4
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000278 [mitotic cell cycle]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0019903 [protein phosphatase binding]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070979 [protein K11-linked ubiquitination]
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 808 aa
92.1 kDa 		No 0
ANAPC4-002
ENSP00000426654
ENST00000510092
Q9UJX5 [Direct mapping]
Anaphase-promoting complex subunit 4
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005829 [cytosol]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0019903 [protein phosphatase binding]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0051301 [cell division]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0070979 [protein K11-linked ubiquitination]
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 809 aa
92.2 kDa 		No 0
ANAPC4-006
ENSP00000421840
ENST00000505991
D6RAP6 [Direct mapping]
Anaphase-promoting complex subunit 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005680 [anaphase-promoting complex]
GO:0030071 [regulation of mitotic metaphase/anaphase transition]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
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 162 aa
18.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.