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Moderate cytoplasmic and membranous positivity was observed in colorectal and thyroid cancers along with few melanomas, ovarian, stomach, pancreatic and liver cancers. Remaining cancers were weakly stained or negative.
Most tumors cells were negative. Cytoplasmic and membranous immunoreactivity of varying intensity was seen in colorectal cancers.
GENE INFORMATION
Gene name
KCNQ1 (HGNC Symbol)
Synonyms
JLNS1, KCNA8, KCNA9, Kv7.1, KVLQT1, LQT, LQT1
Description
Potassium channel, voltage gated KQT-like subfamily Q, member 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. This gene exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. This gene is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]